Kärjä J, Syrjänen S, Usenius T, Vornanen M, Collan Y
Department of Otolaryngology, University of Kuopio, Finland.
Acta Otolaryngol Suppl. 1988;449:145-9. doi: 10.3109/00016488809106398.
11 malignant tumours of the oral region in children under 15 years of age were diagnosed in Finland during the 20-year period from 1961 to 1980; the age adjusted annual incidence rate being 0.31 per 1,000,000 children. 5 cases were intraoral cancer and 5 cases malignant tumours of the major salivary glands. The formalin-fixed tumours were studied using the in situ DNA hybridization technique for Adenovirus, group II, Epstein-Barr and human papillomavirus, type 16. For the first time, evidence was provided for the presence of Epstein-Barr virus in a malignant salivary gland tumour, implicating a possible etiological role for this virus in salivary gland neoplasms.
1961年至1980年的20年间，芬兰诊断出11例15岁以下儿童口腔区域的恶性肿瘤；年龄调整后的年发病率为每100万儿童中有0.31例。5例为口腔癌，5例为大唾液腺恶性肿瘤。使用针对II组腺病毒、爱泼斯坦-巴尔病毒和16型人乳头瘤病毒的原位DNA杂交技术对福尔马林固定的肿瘤进行了研究。首次有证据表明恶性唾液腺肿瘤中存在爱泼斯坦-巴尔病毒，这意味着该病毒在唾液腺肿瘤中可能具有病因学作用。
