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Antimycobacterial activity in vivo of LM427 (rifabutin).

作者信息

Orme I M

机构信息

Department of Microbiology, Colorado State University, Fort Collins 80523.

出版信息

Am Rev Respir Dis. 1988 Nov;138(5):1254-7. doi: 10.1164/ajrccm/138.5.1254.

DOI:10.1164/ajrccm/138.5.1254
PMID:2849349
Abstract

The activity of the rifampin derivative rifabutin (ansamycin; LM427) was tested in vivo against experimental infections of mice with members of the Mycobacterium avium complex (MAC) and a highly virulent strain of Mycobacterium tuberculosis. Rifabutin was moderately effective against an environmental serotype 8 strain of MAC and of significant effectiveness against low dose aerogenic infections with two strains of higher virulence. The drug was also highly effective in causing the rapid resolution of an intravenous M. tuberculosis infection. These data thus contest a previous negative report on the activity of rifabutin in mouse models of M. avium complex.

摘要

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Low-dose aerosol infection model for testing drugs for efficacy against Mycobacterium tuberculosis.
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