Heifets L B, Lindholm-Levy P J, Iseman M D
National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Am Rev Respir Dis. 1988 Mar;137(3):719-21. doi: 10.1164/ajrccm/137.3.719.
The minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC) of rifabutine (ansamycin LM427, spiropiperidyl rifamycin) against rifampin-susceptible and rifampin-resistant strains of Mycobacterium tuberculosis were determined. The MICs for 17 rifampin-susceptible strains were low, falling in a narrow range of 0.06 microgram/ml or less when determined by either the agar-dilution method (in 7H10 or 7H11 agar) or in 7H12 broth (radiometrically or by sampling and colony-forming units [CFU/ml] determination). The MICs of rifabutine for 21 rifampin-resistant strains were much higher, ranging from 0.25 to 16.0 micrograms/ml. The MBCs of rifabutine were 0.125 or 0.25 microgram/ml for rifampin-susceptible strains, and were 4.0 and 32.0 micrograms/ml for two tested rifampin-resistant strains. The MIC/MBC ratio was 1:4 for rifampin-susceptible strains.
测定了利福布汀（安萨霉素LM427，螺哌啶利福霉素）对利福平敏感和利福平耐药结核分枝杆菌菌株的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。17株利福平敏感菌株的MIC较低，通过琼脂稀释法（在7H10或7H11琼脂中）或在7H12肉汤中（通过放射性测量或通过取样和菌落形成单位[CFU/ml]测定）测定时，落在0.06微克/毫升或更低的狭窄范围内。21株利福平耐药菌株的利福布汀MIC要高得多，范围为0.25至16.0微克/毫升。利福布汀对利福平敏感菌株的MBC为0.125或0.25微克/毫升，对两株受试利福平耐药菌株的MBC为40为4.0和32.0微克/毫升。利福平敏感菌株的MIC/MBC比值为1:4。
