Furney S K, Roberts A D, Orme I M
Department of Microbiology, Colorado State University, Fort Collins 80523.
Antimicrob Agents Chemother. 1990 Sep;34(9):1629-32. doi: 10.1128/AAC.34.9.1629.
Disseminated Mycobacterium avium infection is the major cause of bacteremia in patients with acquired immunodeficiency syndrome. We present here a new animal model of this disease, thymectomized C57BL/6 mice that were intravenously infused with monoclonal antibody to selectively deplete CD4+ T cells. The increased susceptibility of such animals to M. avium infection is comparable to that of C57BL/6 beige mice and thus may provide a viable alternative to the latter model. Further, using representative strains of acquired immunodeficiency syndrome-associated M. avium (serotypes 1, 4, and 8 and a rough isolate), we show that the course of such infections in thymectomized, CD4-deficient mice can be markedly restrained and in some cases the infections can be sterilized by treatment over a 120-day period with a regimen containing 40 mg of the new antimycobacterial agent rifabutin per kg (body weight).
播散性鸟分枝杆菌感染是获得性免疫缺陷综合征患者菌血症的主要原因。我们在此展示了一种该疾病的新动物模型，即胸腺切除的C57BL/6小鼠，通过静脉注射单克隆抗体以选择性耗竭CD4+ T细胞。这类动物对鸟分枝杆菌感染易感性的增加与C57BL/6米色小鼠相当，因此可能为后一种模型提供可行的替代方案。此外，使用与获得性免疫缺陷综合征相关的鸟分枝杆菌代表性菌株（血清型1、4和8以及一株粗糙分离株），我们发现胸腺切除、缺乏CD4的小鼠此类感染的病程可得到显著抑制，在某些情况下，通过每千克（体重）含40毫克新型抗分枝杆菌药物利福布汀的方案治疗120天，感染可被清除。
