抗病毒化合物MDL 20,610的作用机制。
Mechanism of action of the antiviral compound MDL 20,610.
作者信息
Kenny M T, Torney H L, Dulworth J K
机构信息
Department of Pharmacology, Merrell Dow Research Institute, Indianapolis, Indiana 46268-0470.
出版信息
Antiviral Res. 1988 Jul;9(4):249-61. doi: 10.1016/0166-3542(88)90056-3.
Abstract
The purpose of this study was to probe the antirhinovirus (RV) mechanism of action of MDL 20,610. Evaluation of the compound's effects on RV RNA synthesis, uncoating of neutral red-sensitized RV, plasma membrane penetration by RV, stabilization of RV against heat (56 degrees C) and low pH (5.0) inactivation, and studies with MDL 20,610-resistant RV mutants indicate that MDL 20,610 binds directly to the RV capsid with subsequent inhibition of acid-mediated virion uncoating.
摘要
本研究的目的是探究MDL 20,610抗鼻病毒（RV）的作用机制。评估该化合物对RV RNA合成、中性红致敏RV的脱壳、RV对质膜的穿透、RV抵御热（56摄氏度）和低pH（5.0）失活的稳定性的影响，以及对MDL 20,610耐药RV突变体的研究表明，MDL 20,610直接与RV衣壳结合，随后抑制酸介导的病毒体脱壳。
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