6-(3,4-二氯苯氧基)-3-(乙硫基)-2-吡啶甲腈抑制脊髓灰质炎病毒脱壳。

6-(3,4-Dichlorophenoxy)-3-(ethylthio)-2-pyridincarbonitrile inhibits poliovirus uncoating.

作者信息

González M E, Almela M J, Yacout M, Carrasco L

机构信息

Centro de Biología Molecular (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Spain.

出版信息

Antimicrob Agents Chemother. 1990 Jun;34(6):1259-61. doi: 10.1128/AAC.34.6.1259.

DOI:10.1128/AAC.34.6.1259

PMID:2168147

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171796/

Abstract

We investigated the mode of action of 6-(3,4-dichlorophenoxy-3-(ethylthio)-2-pyridincarbonitrile against poliovirus. This agent effectively blocked the synthesis of poliovirus proteins and RNA when it was added at the beginning of infection. Poliovirus attachment and internalization into HeLa cells were not inhibited in the presence of the compound; poliovirus uncoating was the target of its activity.

摘要

我们研究了6-(3,4-二氯苯氧基)-3-(乙硫基)-2-吡啶腈对脊髓灰质炎病毒的作用模式。在感染开始时添加该药物，它能有效阻断脊髓灰质炎病毒蛋白质和RNA的合成。在该化合物存在的情况下，脊髓灰质炎病毒对HeLa细胞的附着和内化未受抑制；脊髓灰质炎病毒脱壳是其活性的作用靶点。