Ramírez Juan David, Hernández Carolina
Grupo de Investigaciones Microbiológicas-UR (GIMUR), Programa de Biología, Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá, Colombia.
Grupo de Investigaciones Microbiológicas-UR (GIMUR), Programa de Biología, Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá, Colombia.
Acta Trop. 2018 Aug;184:53-58. doi: 10.1016/j.actatropica.2017.05.005. Epub 2017 May 8.
Chagas disease is a complex zoonosis caused by the kinetoplastid parasite Trypanosoma cruzi. This protozoan exhibits remarkable genetic diversity evinced in at least six Discrete Typing Units (DTUs) with the foreseen emergence of a genotype associated to bats (TcBat). T. cruzi I is the DTU with the broadest geographical distribution and associated to severe cardiomyopathies. In 2011, we published a review questioning the need for genetic subdivision within TcI. However, after six years of intensive research. Herein, we attempted to determine if TcI should be subdivided or not in the light of the current genetic, biological, clinical and ecological data. The future perspectives are discussed.
恰加斯病是一种由动质体寄生虫克氏锥虫引起的复杂人畜共患病。这种原生动物表现出显著的遗传多样性，至少有六个离散型单元（DTUs）体现了这一点，预计还会出现与蝙蝠相关的基因型（TcBat）。克氏锥虫I型是地理分布最广的DTU，与严重的心肌病有关。2011年，我们发表了一篇综述，质疑在克氏锥虫I型内进行基因细分的必要性。然而，经过六年的深入研究。在此，我们试图根据当前的遗传、生物学、临床和生态学数据来确定克氏锥虫I型是否应该细分。并讨论了未来的前景。
