Wojciechowska Irmina, Wojciechowska Aleksandra, Wieszczycka Karolina, Aksamitowski Przemysław, Zembrzuska Joanna, Framski Grzegorz
Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo St. 4, 60-965 Poznan, Poland.
Institute of Chemistry and Technical Electrochemistry, Poznan University of Technology, Berdychowo St. 4, 60-965 Poznan, Poland.
Chem Zvesti. 2017;71(5):953-960. doi: 10.1007/s11696-016-0019-1. Epub 2016 Dec 10.
LC-MS/MS method to determine hydrophobic -alkyloxy substituted amidines: -(2-ethylhexyloxy)pyridine-2-carboximidamide, -(2-ethylhexyloxy)pyridine-3-carboximidamide, -(2-ethylhexyloxy)pyridine-4-carboximidamide, -decyloxy pyridine-2-carboximidamide, -decyloxypyridine-3-carboximidamide and -decyloxypyridine-4-carboximidamide was developed and validated in terms of linearity, precision and accuracy. The developed method was successfully applied to monitor and control the synthesis process. The experimental data points indicated that the straight chain alkyl bromide reacted most rapidly than branched alkyl bromide and the enhancement of the reaction efficiency strongly depended on reaction temperature.
用于测定疏水烷氧基取代脒的液相色谱-串联质谱法：-(2-乙基己氧基)吡啶-2-甲脒、-(2-乙基己氧基)吡啶-3-甲脒、-(2-乙基己氧基)吡啶-4-甲脒、-癸氧基吡啶-2-甲脒、-癸氧基吡啶-3-甲脒和-癸氧基吡啶-4-甲脒，该方法在线性、精密度和准确度方面得到了开发和验证。所开发的方法成功应用于监测和控制合成过程。实验数据点表明，直链烷基溴的反应速度比支链烷基溴快，反应效率的提高强烈依赖于反应温度。
