Xu Youhua, Zhou Hua, Zhu Quan
Faculty of Chinese Medicine, Macau University of Science and TechnologyTaipa, Macau.
State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology)Taipa, Macau.
Front Aging Neurosci. 2017 Apr 27;9:106. doi: 10.3389/fnagi.2017.00106. eCollection 2017.
Progressive cognitive dysfunction is a central characteristic of diabetic encephalopathy (DE). With an aging population, the incidence of DE is rising and it has become a major threat that seriously affects public health. Studies within this decade have indicated the important role of risk factors such as oxidative stress and inflammation on the development of cognitive impairment. With the recognition of the two-way communication between gut and brain, recent investigation suggests that "microbiota-gut-brain axis" also plays a pivotal role in modulating both cognition function and endocrine stability. This review aims to systemically elucidate the underlying impact of diabetes on cognitive impairment.
进行性认知功能障碍是糖尿病性脑病（DE）的核心特征。随着人口老龄化，DE的发病率不断上升，已成为严重影响公众健康的重大威胁。近十年的研究表明，氧化应激和炎症等危险因素在认知障碍的发生发展中起重要作用。随着肠道与大脑之间双向交流的发现，最近的研究表明“微生物群-肠道-脑轴”在调节认知功能和内分泌稳定性方面也起着关键作用。本综述旨在系统阐明糖尿病对认知障碍的潜在影响。
