Lu Jian, Hou Wenlong, Gao Sunan, Zhang Ye, Zong Youming
Department of Anesthesiology, The Second Hospital of Jiaxing, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Department of Anesthesiology, Bengbu Medical College, Bengbu, China.
Front Pharmacol. 2022 Jun 14;13:879745. doi: 10.3389/fphar.2022.879745. eCollection 2022.
With the aging of the world population and advances in medical and health technology, more and more elderly patients are undergoing anesthesia and surgery, and perioperative neurocognitive dysfunction (PND) is receiving increasing attention. The latest definition of PND, published simultaneously in November 2018 in 6 leading journals in the field of anesthesiology, clarifies that PND includes preoperatively cognitive impairment, postoperative delirium, delayed neurocognitive recovery, and postoperative cognitive dysfunction and meets the diagnostic criteria for neurocognitive impairment in the Diagnostic and Statistical Manual of Mental Disorders -fifth edition (DSM-5). The time frame for PND includes preoperatively and within 12 months postoperatively. Recent studies have shown that gut microbiota regulates central nervous function and behavior through the gut microbiota - gut - brain axis, but the role of the axis in the pathogenesis of PND remains unclear. Therefore, this article reviews the mechanism of the role of gut microbiota-gut-brain axis in PND, so as to help explore reasonable early treatment strategies.
随着世界人口老龄化以及医疗卫生技术的进步，越来越多的老年患者接受麻醉和手术，围手术期神经认知功能障碍（PND）日益受到关注。2018年11月同时发表于麻醉学领域6种顶尖期刊的PND最新定义明确指出，PND包括术前认知功能损害、术后谵妄、神经认知恢复延迟以及术后认知功能障碍，且符合《精神疾病诊断与统计手册》第五版（DSM-5）中神经认知损害的诊断标准。PND的时间范围包括术前以及术后12个月内。近期研究表明，肠道微生物群通过肠道微生物群-肠-脑轴调节中枢神经功能和行为，但该轴在PND发病机制中的作用仍不明确。因此，本文综述肠道微生物群-肠-脑轴在PND中作用的机制，以助于探索合理的早期治疗策略。
