心外膜脂肪与心房颤动：综述
Epicardial Fat and Atrial Fibrillation: A Review.
作者信息
Al Chekakie M Obadah, Akar Joseph G
机构信息
University of Colorado, Denver, CO and.
Yale University School of Medicine, New Haven, CT.
出版信息
J Atr Fibrillation. 2012 Apr 14;4(6):483. doi: 10.4022/jafib.483. eCollection 2012 Apr-May.
Abstract
Atrial fibrillation (AF) is a progressive disorder that increases with age. Obesity is an important risk factor for AF. Pericardial fat is an active adipose tissue in close proximity to the heart and has been shown to be a risk factor for structural as well as coronary artery disease independent of body mass index. Recent studies suggest a role of epicardial fat in atrial remodeling as well as AF burden. This review will summarize the recent evidence linking epicardial fat and AF.
摘要
心房颤动（AF）是一种随年龄增长而进展的疾病。肥胖是AF的重要危险因素。心包脂肪是紧邻心脏的一种活跃脂肪组织，已被证明是独立于体重指数的结构及冠状动脉疾病的危险因素。最近的研究表明，心外膜脂肪在心房重构以及房颤负荷中起作用。本综述将总结最近关于心外膜脂肪与房颤之间联系的证据。
相似文献
1
Epicardial Fat and Atrial Fibrillation: A Review.心外膜脂肪与心房颤动：综述
J Atr Fibrillation. 2012 Apr 14;4(6):483. doi: 10.4022/jafib.483. eCollection 2012 Apr-May.
2
Epicardial Adipose Tissue and Cardiac Arrhythmias: Focus on Atrial Fibrillation.心外膜脂肪组织与心律失常：聚焦心房颤动
Front Cardiovasc Med. 2022 Jun 30;9:932262. doi: 10.3389/fcvm.2022.932262. eCollection 2022.
3
Disease-treatment interactions in the management of patients with obesity and diabetes who have atrial fibrillation: the potential mediating influence of epicardial adipose tissue.肥胖和糖尿病合并心房颤动患者管理中的疾病-治疗相互作用：心外膜脂肪组织的潜在中介影响。
Cardiovasc Diabetol. 2019 Sep 24;18(1):121. doi: 10.1186/s12933-019-0927-9.
4
Pericardial fat and atrial fibrillation: Epidemiology, mechanisms and interventions.心包脂肪与心房颤动：流行病学、机制及干预措施
Int J Cardiol. 2015 Sep 15;195:98-103. doi: 10.1016/j.ijcard.2015.05.129. Epub 2015 May 21.
5
Left Atrial Epicardial Fat Volume Is Associated With Atrial Fibrillation: A Prospective Cardiovascular Magnetic Resonance 3D Dixon Study.左心外膜脂肪体积与心房颤动相关：前瞻性心血管磁共振 3D Dixon 研究。
J Am Heart Assoc. 2018 Mar 23;7(6):e008232. doi: 10.1161/JAHA.117.008232.
6
Electroanatomical Remodeling of the Atria in Obesity: Impact of Adjacent Epicardial Fat.肥胖患者心房的电重构：心外膜脂肪的影响。
JACC Clin Electrophysiol. 2018 Dec;4(12):1529-1540. doi: 10.1016/j.jacep.2018.08.014. Epub 2018 Nov 1.
7
The Role of Pericardial and Epicardial Fat in Atrial Fibrillation Pathophysiology and Ablation Outcomes.心包脂肪和心外膜脂肪在心房颤动病理生理学及消融结果中的作用
J Atr Fibrillation. 2013 Feb 12;5(5):790. doi: 10.4022/jafib.790. eCollection 2013 Feb-Mar.
8
Associations of Epicardial, Abdominal, and Overall Adiposity With Atrial Fibrillation.心外膜、腹部及总体肥胖与心房颤动的关联。
Circ Arrhythm Electrophysiol. 2016 Dec;9(12). doi: 10.1161/CIRCEP.116.004378.
9
Pericardial fat is strongly associated with atrial fibrillation after coronary artery bypass graft surgery†.心包脂肪与冠状动脉搭桥手术后的心房颤动密切相关†。
Eur J Cardiothorac Surg. 2014 Dec;46(6):1014-20; discussion 1020. doi: 10.1093/ejcts/ezu043. Epub 2014 Mar 20.
10
Association Between Posterior Left Atrial Adipose Tissue Mass and Atrial Fibrillation.左心房后部脂肪组织质量与心房颤动之间的关联
Circ Arrhythm Electrophysiol. 2017 Feb;10(2). doi: 10.1161/CIRCEP.116.004614.
引用本文的文献
1
Coronary Artery Inflammation and Epicardial Adipose Tissue Volume in Relation with Atrial Fibrillation Development.冠状动脉炎症及心外膜脂肪组织体积与心房颤动发生的关系
Diagnostics (Basel). 2025 Aug 11;15(16):2003. doi: 10.3390/diagnostics15162003.
2
Clinical and electrophysiological significance of residual unipolar voltage after performing pulmonary vein isolation in patients with paroxysmal atrial fibrillation.阵发性心房颤动患者行肺静脉隔离术后残余单极电压的临床及电生理意义
J Arrhythm. 2025 May 19;41(3):e70092. doi: 10.1002/joa3.70092. eCollection 2025 Jun.
3
Epicardial Fat in Heart Failure with Preserved Ejection Fraction Compared with Reduced Ejection Fraction.射血分数保留的心力衰竭与射血分数降低的心力衰竭中的心外膜脂肪比较
J Clin Med. 2024 Sep 18;13(18):5533. doi: 10.3390/jcm13185533.
4
Dual vs Single Cardioversion of Atrial Fibrillation in Patients With Obesity: A Randomized Clinical Trial.肥胖患者心房颤动的双相 vs 单相复律：一项随机临床试验。
JAMA Cardiol. 2024 Jul 1;9(7):641-648. doi: 10.1001/jamacardio.2024.1091.
5
Comparative study of left atrium epicardial fat tissue pattern using persistent homology approach.应用持久同调方法对左心房心外膜脂肪组织模式的比较研究。
BMC Res Notes. 2022 Sep 15;15(1):299. doi: 10.1186/s13104-022-06173-2.
6
Quantification of Cardiac Adipose Tissue in Failing and Nonfailing Human Myocardium.心力衰竭和非心力衰竭人类心肌中心脏脂肪组织的定量分析。
J Am Heart Assoc. 2022 Jul 5;11(13):e025405. doi: 10.1161/JAHA.121.025405. Epub 2022 Jun 22.
本文引用的文献
1
Pericardial fat is associated with atrial fibrillation severity and ablation outcome.心包脂肪与心房颤动严重程度和消融结果相关。
J Am Coll Cardiol. 2011 Apr 26;57(17):1745-51. doi: 10.1016/j.jacc.2010.11.045.
2
Quantitative analysis of quantity and distribution of epicardial adipose tissue surrounding the left atrium in patients with atrial fibrillation and effect of recurrence after ablation.定量分析心房颤动患者左心房周围心外膜脂肪组织的数量和分布及其消融后复发的影响。
Am J Cardiol. 2011 May 15;107(10):1498-503. doi: 10.1016/j.amjcard.2011.01.027. Epub 2011 Mar 15.
3
Total and interatrial epicardial adipose tissues are independently associated with left atrial remodeling in patients with atrial fibrillation.心外膜脂肪组织总量和房间隔与房颤患者左房重构独立相关。
J Cardiovasc Electrophysiol. 2011 Jun;22(6):647-55. doi: 10.1111/j.1540-8167.2010.01993.x. Epub 2011 Jan 15.
4
Decreased adiponectin and increased inflammation expression in epicardial adipose tissue in coronary artery disease.冠心病患者心外膜脂肪组织中脂联素减少和炎症表达增加。
Cardiovasc Diabetol. 2011 Jan 12;10:2. doi: 10.1186/1475-2840-10-2.
5
Effect of epicardial fat on electroanatomical mapping and epicardial catheter ablation.心外膜脂肪对心外膜导管消融的影响。
J Am Coll Cardiol. 2010 Oct 12;56(16):1320-7. doi: 10.1016/j.jacc.2010.04.054.
6
Pericardial fat is independently associated with human atrial fibrillation.心包脂肪与人类心房颤动独立相关。
J Am Coll Cardiol. 2010 Aug 31;56(10):784-8. doi: 10.1016/j.jacc.2010.03.071.
7
Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study.心包脂肪与心房颤动的患病率相关：弗雷明汉心脏研究。
Circ Arrhythm Electrophysiol. 2010 Aug;3(4):345-50. doi: 10.1161/CIRCEP.109.912055. Epub 2010 Jun 17.
8
Left atrial epicardial adiposity and atrial fibrillation.左心外膜脂肪与心房颤动。
Circ Arrhythm Electrophysiol. 2010 Jun;3(3):230-6. doi: 10.1161/CIRCEP.110.957241. Epub 2010 May 26.
9
Mathematical modeling of epicardial RF ablation of atrial tissue with overlying epicardial fat.伴有心外膜脂肪覆盖的心房组织心外膜射频消融的数学建模
Open Biomed Eng J. 2010 Feb 4;4:47-55. doi: 10.2174/1874120701004020047.
10
Echocardiographic epicardial fat: a review of research and clinical applications.超声心动图心外膜脂肪：研究和临床应用综述。
J Am Soc Echocardiogr. 2009 Dec;22(12):1311-9; quiz 1417-8. doi: 10.1016/j.echo.2009.10.013.
Zotero 插件