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心房颤动患者中风预防的新选择

New Stroke Prophylaxis Options in Atrial Fibrillation Patients.

作者信息

Thomas George, Lerman Bruce B

机构信息

Division of Cardiology, Cornell University Medical Center, New York Presbyterian Hospital, 520 E. 70th Street, Starr 4, New York, New York 10021.

出版信息

J Atr Fibrillation. 2013 Feb 12;5(5):462. doi: 10.4022/jafib.462. eCollection 2013 Feb-Mar.

Abstract

Atrial Fibrillation (AF) is an epidemic that is increasing in size and scope. AF can have many symptoms and cause a variety of negative health impacts.The most important health risk of AF is the increased risk of stroke and systemic thromboembolism.Oral anticoagulation with warfarin has been the gold standard for stroke risk reduction in AF, but new drugs and treatment strategies for AF are changing clinical practice. These new advances could offer better tailoring of treatments to patients with high risk of stroke while reducing the potential bleeding complications.

摘要

心房颤动(AF)是一种规模和范围都在不断扩大的流行病。AF可能有多种症状,并会对健康造成各种负面影响。AF最重要的健康风险是中风和全身性血栓栓塞风险增加。使用华法林进行口服抗凝一直是降低AF中风风险的金标准,但AF的新药和治疗策略正在改变临床实践。这些新进展可以为中风高危患者提供更个性化的治疗,同时减少潜在的出血并发症。

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本文引用的文献

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Apixaban versus warfarin in patients with atrial fibrillation.阿哌沙班与华法林用于房颤患者。
N Engl J Med. 2011 Sep 15;365(11):981-92. doi: 10.1056/NEJMoa1107039. Epub 2011 Aug 27.
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Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.利伐沙班与华法林用于非瓣膜性心房颤动。
N Engl J Med. 2011 Sep 8;365(10):883-91. doi: 10.1056/NEJMoa1009638. Epub 2011 Aug 10.
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Apixaban in patients with atrial fibrillation.阿哌沙班用于房颤患者。
N Engl J Med. 2011 Mar 3;364(9):806-17. doi: 10.1056/NEJMoa1007432. Epub 2011 Feb 10.
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Stroke risk and antithrombotic strategies in atrial fibrillation.心房颤动的卒中风险与抗栓策略。
Stroke. 2010 Nov;41(11):2705-13. doi: 10.1161/STROKEAHA.110.589218. Epub 2010 Oct 7.

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