Stamenova Vessela, Gao Fuqiang, Black Sandra E, Schwartz Michael L, Kovacevic Natasha, Alexander Michael P, Levine Brian
Rotman Research Institute at Baycrest, Toronto, ON, Canada.
LC Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Cortex. 2017 Jun;91:316-326. doi: 10.1016/j.cortex.2017.04.003. Epub 2017 Apr 15.
Recognition memory can be subdivided into two processes: recollection (a contextually rich memory) and familiarity (a sense that an item is old). The brain network supporting recognition encompasses frontal, parietal and medial temporal regions. Which specific regions within the frontal lobe are critical for recollection vs. familiarity, however, are unknown; past studies of focal lesion patients have yielded conflicting results. We examined patients with focal lesions confined to medial polar (MP), right dorsal frontal (RDF), right frontotemporal (RFT), left dorsal frontal (LDF), temporal, and parietal regions and matched controls. A series of words and their humorous definitions were presented either auditorily or visually to all participants. Recall, recognition, and source memory were tested at 30 min and 24 h delay, along with "remember/know" judgments for recognized items. The MP, RDF, temporal and parietal groups were impaired on subjectively reported recollection; their intact recognition performance was supported by familiarity. None of the groups were impaired on cued recall, recognition familiarity or source memory. These findings suggest that the MP and RDF regions, along with parietal and temporal regions, are necessary for subjectively-reported recollection, while the LDF and right frontal ventral regions, as those affected in the RTF group, are not.
回忆（一种情境丰富的记忆）和熟悉感（一种觉得某个项目是旧的感觉）。支持再认的脑网络包括额叶、顶叶和内侧颞叶区域。然而，额叶内哪些特定区域对回忆和熟悉感至关重要尚不清楚；过去对局灶性病变患者的研究结果相互矛盾。我们研究了局限于内侧极（MP）、右侧背侧额叶（RDF）、右侧额颞叶（RFT）、左侧背侧额叶（LDF）、颞叶和顶叶区域的局灶性病变患者及匹配的对照组。向所有参与者以听觉或视觉方式呈现一系列单词及其幽默的定义。在延迟30分钟和24小时时测试回忆、再认和来源记忆，以及对已识别项目的“记得/知道”判断。MP、RDF、颞叶和顶叶组在主观报告的回忆方面受损；他们完整的再认表现是由熟悉感支持的。没有一组在线索回忆、再认熟悉感或来源记忆方面受损。这些发现表明，MP和RDF区域以及顶叶和颞叶区域对于主观报告的回忆是必要的，而LDF和右侧额腹侧区域（如RTF组中受影响的区域）则不是。
