Frithsen Amy, Miller Michael B
Department of Psychological & Brain Sciences, Building 251, University of California, Santa Barbara, Santa Barbara, CA 93106-9660, USA.
Neuropsychologia. 2014 Aug;61:31-44. doi: 10.1016/j.neuropsychologia.2014.06.011. Epub 2014 Jun 17.
Numerous neuroimaging studies have shown a dissociation within the left posterior parietal cortex (PPC) between recollection and familiarity, with dorsal regions routinely active during familiarity and ventral regions active during recollection. The two most common methods for separating the neural correlates of these retrieval states are the remember/know paradigm and tests probing source memory. While relatively converging results have been found using these methods, the literature is lacking an adequate and direct comparison of the two procedures. We directly compared these two methodologies and found differences in both the magnitude and extent of activation within the left PPC. During familiarity, dorsal PPC regions were more strongly activated by the source test, while the remember/know test led to stronger recollection-related activations within the ventral regions of the PPC. This modulation of PPC activity is particularly important because it suggests that the neural correlates of familiarity and recollection depend on how they are operationalized. Previous assumptions that remember/know and source memory tests are functionally equivalent should therefore be re-evaluated. Additionally, any theories attempting to explain the functional role of the PPC during memory retrieval must take these differences into account.
众多神经影像学研究表明，在左后顶叶皮层（PPC）内，回忆和熟悉感之间存在分离现象，背侧区域在熟悉感期间通常活跃，而腹侧区域在回忆期间活跃。分离这些检索状态的神经关联的两种最常见方法是记住/知道范式和探测源记忆的测试。虽然使用这些方法已发现相对趋同的结果，但文献中缺乏对这两种程序的充分且直接的比较。我们直接比较了这两种方法，发现左PPC内激活的程度和范围均存在差异。在熟悉感期间，源测试对PPC背侧区域的激活更强，而记住/知道测试则导致PPC腹侧区域内与回忆相关的激活更强。PPC活动的这种调节尤为重要，因为它表明熟悉感和回忆的神经关联取决于它们的操作方式。因此，应重新评估之前关于记住/知道和源记忆测试在功能上等效的假设。此外，任何试图解释PPC在记忆检索过程中的功能作用的理论都必须考虑到这些差异。
