Rotman Research Institute, Baycrest, 3560 Bathurst Street, Toronto, ON M6A 2E1 Canada.
J Cogn Neurosci. 2011 Dec;23(12):3804-16. doi: 10.1162/jocn_a_00050. Epub 2011 May 12.
Medial-temporal, parietal, and pFC regions have been implicated in recollection and familiarity, but existing evidence from neuroimaging and patient studies is limited and conflicting regarding the role of specific regions within pFC in these memory processes. We report a study of 20 patients who had undergone resection of right frontal lobe tumors and 20 matched healthy control participants. The location and extent of lesions were traced on the patients' scans. A process dissociation procedure was employed to yield estimates of the contributions of recollection and familiarity in verbal recognition performance. Group comparisons revealed deficits in recollection but not familiarity in the patient group relative to their healthy counterparts. We found a positive relationship between estimates of familiarity and lesion sizes in the right inferior pFC (BA 11, 47) which was significant upon bootstrap resampling. These results are discussed in terms of prior work linking this area to an overextended sense of familiarity.
内侧颞叶、顶叶和额前皮质区域与记忆的再认和熟悉度有关，但神经影像学和患者研究的现有证据表明，额前皮质特定区域在这些记忆过程中的作用有限且相互矛盾。我们报告了一项对 20 名接受右额叶肿瘤切除术的患者和 20 名匹配的健康对照组参与者的研究。在患者的扫描图像上追踪病变的位置和范围。采用加工分离程序得出言语识别表现中再认和熟悉度的贡献估计。与健康对照组相比，患者组在再认方面表现出缺陷，但在熟悉度方面没有缺陷。我们发现，在右侧下额前皮质（BA11、47）的熟悉度估计与病变大小之间存在正相关关系，这一关系在 bootstrap 重采样后具有统计学意义。这些结果是根据先前将该区域与过度扩展的熟悉感联系起来的研究进行讨论的。
