Fullston Tod, McPherson Nicole O, Zander-Fox Deirdre, Lane Michelle
Discipline of Obstetrics & GynaecologyAdelaide Medical School, Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia
Freemason's Foundation Centre for Men's HealthThe University of Adelaide, Adelaide, South Australia, Australia.
J Endocrinol. 2017 Aug;234(2):F1-F6. doi: 10.1530/JOE-16-0382. Epub 2017 May 12.
Animal and human studies demonstrate that acquired paternal traits can impair both a male's fertility and the health of his offspring, including advanced age, smoking, stress, trauma, under-nutrition, infection, toxin exposure, and obesity. Many of these factors lead to similar changes to neurological, behavioural, and/or metabolic functioning in offspring. The molecular mechanisms that both respond to the paternal environment and act to transmit traits to offspring are beginning to emerge. This review focuses on three vices of men (alcohol consumption, overweight/obesity, and tobacco smoking) that damage fertility and pose risks to offspring health. These vices are not only the three most prevalent but are also leading risk factors for death and disability adjusted life years (DALYs) worldwide. Moreover, given that these vices are predominantly self-inflicted, interventions aimed at mitigating their consequences are readily identified.
动物和人体研究表明，后天获得的父系特征会损害男性的生育能力及其后代的健康，这些特征包括高龄、吸烟、压力、创伤、营养不良、感染、接触毒素和肥胖。其中许多因素会导致后代的神经、行为和/或代谢功能发生类似变化。对父系环境做出反应并将特征传递给后代的分子机制正开始显现。本综述重点关注损害生育能力并对后代健康构成风险的男性三大恶习（饮酒、超重/肥胖和吸烟）。这些恶习不仅是最普遍的三种，也是全球死亡和残疾调整生命年（DALYs）的主要危险因素。此外，鉴于这些恶习主要是自我造成的，旨在减轻其后果的干预措施很容易确定。
