Marinelli Daniela, Gaspari Laura, Pedotti Paola, Taioli Emanuela
Molecular and Genetic Epidemiology Unit, Ospedale Policlinico IRCCS, Milano, Italy.
Int J Hyg Environ Health. 2004 Jul;207(3):185-92. doi: 10.1078/1438-4639-00283.
This article aims at evaluating the impact of cigarette smoking and alcohol consumption on different semen parameters (volume, concentration, motility, morphology, total sperm count and viability), by reviewing all the published literature on smoking, alcohol and sperm morphology. The studies on smoking and sperm abnormalities show a limited effect of smoking on conventional sperm parameters. The data on alcohol are more sparse, and show an apparent protective effect of moderate alcohol drinking on sperm parameters, probably due to the antioxidant effect of some alcoholic beverages. Unfortunately, none of the studies that considered both alcohol and smoking habits conducted the analysis of the joint effect of the two exposure factors. More standardized laboratory assays and increased sample size studies involving subjects with various level of exposure to alcohol and smoking are needed to better establish the role of these factors in male infertility.
本文旨在通过回顾所有已发表的关于吸烟、饮酒与精子形态的文献，评估吸烟和饮酒对不同精液参数（体积、浓度、活力、形态、精子总数和存活率）的影响。关于吸烟与精子异常的研究表明，吸烟对传统精子参数的影响有限。关于饮酒的数据更为稀少，且显示适度饮酒对精子参数有明显的保护作用，这可能归因于某些酒精饮料的抗氧化作用。遗憾的是，没有一项同时考虑饮酒和吸烟习惯的研究对这两种暴露因素的联合效应进行分析。需要更标准化的实验室检测以及纳入不同酒精和吸烟暴露水平受试者的更大样本量研究，以更好地确定这些因素在男性不育中的作用。
