Kempf C, Michel M R, Kohler U, Koblet H, Oetliker H
Institute of Hygiene and Medical Microbiology, University of Bern, Switzerland.
Biosci Rep. 1988 Jun;8(3):241-54. doi: 10.1007/BF01115041.
The mechanism of the processes leading to membrane fusion is as yet unknown. In this report we demonstrate that changes in membrane potential and potassium fluxes correlate with Semliki Forest virus induced cell-cell fusion at mildly acidic pH. The changes observed occur only at pH's below 6.2 corresponding to values required to trigger the fusion process. A possible role of these alterations of the plasma membrane related to membrane fusion phenomena is discussed.
导致膜融合的过程机制目前尚不清楚。在本报告中，我们证明了膜电位和钾离子通量的变化与辛德毕斯病毒在轻度酸性pH条件下诱导的细胞间融合相关。观察到的这些变化仅发生在pH低于6.2时，这与触发融合过程所需的值相对应。本文讨论了这些与细胞膜融合现象相关的质膜改变可能发挥的作用。
