Kim Tae In, Ahn Hye-Jin, Kang In Hye, Jeong Ki-Heon, Kim Nack In, Shin Min Kyung
Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.
Photodermatol Photoimmunol Photomed. 2017 Sep;33(5):253-259. doi: 10.1111/phpp.12312. Epub 2017 Jun 30.
Photodynamic therapy (PDT) has been reported as an effective alternative treatment for patients with acne.
To evaluate the efficacy and safety of DL-PDT in moderate to severe acne and to compare outcomes with those of laser-assisted daylight photodynamic therapy.
Patients were randomly assigned to either a DL-PDT group (D group) or a fractional laser-assisted DL-PDT group (F group). The outcomes were assessed by measuring acne lesion counts and severity grade at 4, 8, 12, and 16 weeks after therapy commenced.
Twenty-eight subjects completed the study. Compared with baseline, the mean inflammatory lesion counts significantly decreased by 36.0% in the D group and 51.8% in the F group at 8 weeks (P<.001). The mean acne severity grades in both groups significantly decreased starting at 4 weeks (P=.012), and the beneficial effects lasted 16 weeks.
DL-PDT with MAL shows clinically good responses to inflammatory lesions and is well tolerated in patients with moderate to severe acne.
光动力疗法（PDT）已被报道为痤疮患者的一种有效替代治疗方法。
评估深层光动力疗法（DL-PDT）治疗中度至重度痤疮的疗效和安全性，并将结果与激光辅助日光光动力疗法的结果进行比较。
将患者随机分为DL-PDT组（D组）或分次激光辅助DL-PDT组（F组）。在治疗开始后的4、8、12和16周，通过测量痤疮皮损数量和严重程度分级来评估结果。
28名受试者完成了研究。与基线相比，D组在8周时平均炎性皮损数量显著减少36.0%，F组减少51.8%（P<0.001）。两组的平均痤疮严重程度分级从4周开始显著降低（P=0.012），且有益效果持续16周。
含甲基氨基酮戊酸的DL-PDT对炎性皮损显示出良好的临床反应，且中度至重度痤疮患者耐受性良好。
