Department of Biomechatronic Engineering, National Ilan University, Yilan, Taiwan.
Department of Human Physiology, Faculty of Medical Sciences; University of Warmia and Mazury, Olsztyn, Poland.
Psychiatry Res. 2017 Aug;254:290-300. doi: 10.1016/j.psychres.2017.05.008. Epub 2017 May 6.
The present study examines whether housing style (e.g., single housing, same-strain-grouped housing, and different-strain-grouped housing) and rat strain (e.g., spontaneous hypertension rats [SHR] and Wistar-Kyoto rats [WKY]) mediate motor function and anxiety behavior in the open field task. From week 4 through week 10 following birth, the rats were measured 30min for locomotor activity and anxiety once per week in the open field task. The SHR rats exhibited hyperactivity in total distance traveled and movement time to form the animal model of ADHD. The SHR rats spent more time inside the square and crossed the inside-outside line more often than the WKY rats, indicating the SHR rats exhibited less anxiety behavior. The different-strain-grouped housing style (but neither the same-strain-grouped housing style nor the single housing style) decreased total distance traveled and facilitated anxiety behavior. The motor function was negatively correlated with anxiety behavior for SHR rats but not for WKY rats. Housing styles had a negative correlation between motor function and anxiety behavior. The present findings provide some insights regarding how social factors (such as housing style) affect motor function and anxiety behavior related to ADHD in a clinical setting.
本研究旨在探讨住房风格（如单人间、同种群分组住房和不同种群分组住房）和大鼠品系（如自发性高血压大鼠 [SHR] 和 Wistar-Kyoto 大鼠 [WKY]）是否会影响旷场任务中的运动功能和焦虑行为。从出生后的第 4 周到第 10 周，每周对大鼠进行 30 分钟的旷场任务，以测量其运动活动和焦虑行为。SHR 大鼠表现出总行进距离和运动时间的过度活跃，形成 ADHD 的动物模型。与 WKY 大鼠相比，SHR 大鼠在正方形内花费的时间更多，穿过内外线的次数也更多，表明 SHR 大鼠的焦虑行为较少。不同种群分组的住房风格（而非同种群分组的住房风格或单人间的住房风格）减少了总行进距离，并促进了焦虑行为。对于 SHR 大鼠，运动功能与焦虑行为呈负相关，但对于 WKY 大鼠则不然。住房风格与运动功能和焦虑行为之间存在负相关。本研究结果为了解社会因素（如住房风格）如何影响 ADHD 相关的运动功能和焦虑行为提供了一些线索。
