人类作为终极伤口愈合模型：研究皮肤脂质组的策略
Human as the Ultimate Wound Healing Model: Strategies for Studies Investigating the Dermal Lipidome.
作者信息
Wijesinghe Dayanjan S, Warncke Urszula Osinska, Diegelmann Robert F
机构信息
Department of Pharmacotherapy and Outcomes Sciences, Virginia Commonwealth University School of Pharmacy, Richmond, Virginia 23298.
C. Kenneth and Dianne Wright Center for Clinical and Translational Research (CCTR), Virginia Commonwealth University Richmond, Virginia 23298.
出版信息
Curr Dermatol Rep. 2016 Dec;5(4):244-251. doi: 10.1007/s13671-016-0156-3. Epub 2016 Oct 3.
PURPOSE OF REVIEW
Educate the reader of the multiple roles undertaken by the human epidermal lipidome and the experimental techniques of measuring them.
RECENT FINDINGS
Damage to skin elicits a wound healing process that is capped by the recreation of the lipid barrier. In addition to barrier function, lipids also undertake an active signaling role during wound healing. Achievement of these multiple functions necessitates a significant complexity and diversity in the lipidome resulting in a composition that is unique to the human skin. As such, any attempts to delineate the function of the lipidome during the wound healing process in humans need to be addressed via studies undertaken in humans.
SUMMARY
The human cutaneous lipidome is unique and play a functionally significant role in maintaining barrier and regulating wound healing. Modern mass spectrometry and Raman spectroscopy based methods enable the investigation epidermal lipidome with respect to those functions.
综述目的
向读者介绍人类表皮脂质组所承担的多种作用以及测量它们的实验技术。
最新发现
皮肤损伤引发伤口愈合过程，该过程以脂质屏障的重新形成而告终。除了屏障功能外，脂质在伤口愈合过程中还发挥着积极的信号传导作用。要实现这些多种功能，脂质组必须具有显著的复杂性和多样性，从而形成人类皮肤特有的组成。因此，任何试图描述人类伤口愈合过程中脂质组功能的尝试都需要通过在人体上进行的研究来解决。
总结
人类皮肤脂质组是独特的，在维持屏障和调节伤口愈合方面发挥着重要的功能作用。基于现代质谱和拉曼光谱的方法能够针对这些功能研究表皮脂质组。
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