Schneeman B O, Cimmarusti J, Cohen W, Downes L, Lefevre M
J Nutr. 1984 Jul;114(7):1320-6. doi: 10.1093/jn/114.7.1320.
Several studies have suggested that dietary fibers, especially water-soluble sources, are effective agents for lowering plasma cholesterol. This study was undertaken to determine the effect of various fibers on the composition of apoproteins in high density lipoproteins. Rats were fed experimental diets that contained either 20% wheat bran, oat bran or cellulose or 5% pectin or guar gum for 4 weeks. Final body weight was similar among groups. HDL cholesterol and total apoprotein concentrations were not significantly altered by diet. The percentage of apo A-I was significantly elevated and apo E and the apo C's were significantly lower in the guar gum group relative to the wheat bran group. Lecithin cholesterol acyl transferase activity and the C-II-to-C-III ratio were highest in the guar gum group. Differences in the absorption and subsequent metabolism of lipid could account for differences in HDL composition.
多项研究表明，膳食纤维，尤其是水溶性膳食纤维，是降低血浆胆固醇的有效物质。本研究旨在确定各种纤维对高密度脂蛋白中载脂蛋白组成的影响。给大鼠喂食含20%麦麸、燕麦麸或纤维素或5%果胶或瓜尔豆胶的实验性饮食，持续4周。各组最终体重相似。饮食对高密度脂蛋白胆固醇和总载脂蛋白浓度无显著影响。与麦麸组相比，瓜尔豆胶组载脂蛋白A-I的百分比显著升高，载脂蛋白E和载脂蛋白C显著降低。瓜尔豆胶组卵磷脂胆固醇酰基转移酶活性和C-II与C-III的比值最高。脂质吸收及后续代谢的差异可能导致高密度脂蛋白组成的差异。
