Vesoulis Zachary A, Galindo Rafael, Ornstein Bradley W, White Andrew J
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Department of Neurology, Division of Pediatric & Developmental Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Child Neurol Open. 2014 Nov 10;1(1):2329048X14550505. doi: 10.1177/2329048X14550505. eCollection 2014 Jul-Sep.
We describe a case of neuro-Behçet disease diagnosed in a 12-year-old girl. This patient presented with recurrent oral ulcers, incontinence, spastic gait, blurry vision, and asymmetrical lower extremity hypertonia. Extensive testing revealed punctate lesions through the central nervous system, vitritis, papillitis, and uveitis. A thorough infectious and neoplastic workup was negative. She was treated with pulse steroids and azathioprine with gradual improvement in her gait and ophthalmologic findings. Although rare, primary neuro-Behçet should be considered in pediatric patients with neurologic abnormalities and recurrent aphthous ulcers without other explanation.
我们描述了一例在一名12岁女孩中诊断出的神经白塞病病例。该患者出现复发性口腔溃疡、尿失禁、痉挛性步态、视力模糊和双下肢不对称性张力亢进。广泛检查发现贯穿中枢神经系统的点状病变病变、玻璃体炎、视乳头炎和葡萄膜炎。全面的感染性和肿瘤性检查结果均为阴性。她接受了脉冲类固醇和硫唑嘌呤治疗，步态和眼科检查结果逐渐改善。虽然罕见，但对于有神经异常和复发性阿弗他溃疡且无其他解释的儿科患者，应考虑原发性神经白塞病。
