重组小鼠干扰素-β对小鼠巨细胞病毒复制的影响。
Effect of recombinant murine interferon-beta on the replication of murine cytomegalovirus.
作者信息
Nakamura K, Eizuru Y, Minamishima Y
机构信息
Department of Microbiology, Miyazaki Medical College.
出版信息
Microbiol Immunol. 1988;32(9):925-31. doi: 10.1111/j.1348-0421.1988.tb01454.x.
Pretreatment of mouse embryo fibroblasts (MEF) with recombinant murine interferon-beta (rMuIFN-beta) induced a high level of intracellular 2',5'-oligoadenylate (2-5A) synthetase activity. However, murine cytomegalovirus (MCMV) replicated under such condition, indicating that MCMV is relatively insensitive in vitro to rMuIFN-beta. Thus, there was a dissociation of 2-5A synthetase activity and antiviral activity against MCMV. In contrast to MCMV, the two parameters were closely associated in the case of vesicular stomatitis virus (VSV).
用重组鼠干扰素-β（rMuIFN-β）预处理小鼠胚胎成纤维细胞（MEF）可诱导高水平的细胞内2',5'-寡腺苷酸（2-5A）合成酶活性。然而，鼠巨细胞病毒（MCMV）在这种条件下仍能复制，这表明MCMV在体外对rMuIFN-β相对不敏感。因此，2-5A合成酶活性与针对MCMV的抗病毒活性之间存在解离。与MCMV相反，在水疱性口炎病毒（VSV）的情况下，这两个参数密切相关。
Zotero 插件