Marcial G, Villena J, Faller G, Hensel A, de Valdéz G Font
1 Centro de Referencia para Lactobacilos (CERELA)-CONICET, Chacabuco 145, 4000 San Miguel de Tucumán, Argentina.
2 University of Münster, Institute for Pharmaceutical Biology and Phytochemistry, Corrensstrasse 48, 48149 Münster, Germany.
Benef Microbes. 2017 May 30;8(3):451-461. doi: 10.3920/BM2016.0186. Epub 2017 May 15.
This work evaluated the ability of the probiotic Streptococcus thermophilus CRL1190 strain and its exopolysaccharides to adhere to gastric mucosa. Probiotic bacteria attachment to the human stomach epithelium was confirmed in human stomach tissue samples and the gastric epithelial cell line AGS. In addition, it was demonstrated that S. thermophilus CRL1190 strain reduced Helicobacter pylori adhesion and attenuated inflammatory response in AGS cells. This is the first demonstration of the capacity of S. thermophilus CRL1190 to adhere to the stomach gastric mucosa, and improve protection against H. pylori through the reduction of its adhesion and the modulation of the inflammatory response. Therefore, S. thermophilus CRL1190 fermented milk is a good candidate for further in vivo studying of the protective effect of functional food against H. pylori infection and gastric inflammatory damage.
本研究评估了益生菌嗜热链球菌CRL1190菌株及其胞外多糖粘附于胃黏膜的能力。在人胃组织样本和胃上皮细胞系AGS中证实了益生菌细菌与人胃上皮的附着。此外，还证明嗜热链球菌CRL1190菌株可减少幽门螺杆菌的粘附并减轻AGS细胞中的炎症反应。这是首次证明嗜热链球菌CRL1190具有粘附于胃黏膜的能力，并通过减少幽门螺杆菌的粘附和调节炎症反应来增强对幽门螺杆菌的保护作用。因此，嗜热链球菌CRL1190发酵乳是进一步体内研究功能性食品对幽门螺杆菌感染和胃炎症损伤保护作用的良好候选物。
