Eide Therkelsen Helena, Enger Rune, Eide Per Kristian, Ringstad Geir
Faculty of Medicine, University of Oslo, Oslo, Norway.
GliaLab and the Letten Centre, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
J Cereb Blood Flow Metab. 2025 Apr;45(4):581-599. doi: 10.1177/0271678X251316392. Epub 2025 Jan 25.
A potential two-way passage of cells and substances between the brain and skull bone marrow may open for new insights into neurological disease. The arachnoid membrane was traditionally considered to restrict cells and larger molecules in CSF from entering the dura and bone marrow directly. However, new data on exchange between brain and skull bone marrow have recently emerged. Here, we conducted a systematic literature to answer the question: What is the current evidence regarding the movement of cells and molecules between the brain and skull bone marrow, spanning CSF and meninges? We excluded studies related to head or skull trauma, cranial fractures or defects, cancer invasion, CSF leakage, spontaneous intracranial hypotension, spinal dura mater, and studies solely focusing on meningeal lymphatic vessels or the passage of substances from CSF to meningeal lymphatic vessels. The review identified 16 studies that provide evidence of communication between the brain, meninges and skull bone marrow. Cells (such as B and T cells and neutrophils), bacteria, and substances (tracers, drug compounds) have been reported to pass between the brain and skull bone. However, most studies are performed in rodents, emphasizing the need for translation to humans.
大脑与颅骨骨髓之间潜在的细胞和物质双向通道可能为神经疾病的新见解打开大门。传统上认为蛛网膜会限制脑脊液中的细胞和大分子直接进入硬脑膜和骨髓。然而，最近出现了关于大脑与颅骨骨髓之间交换的新数据。在这里，我们进行了一项系统的文献研究，以回答以下问题：关于跨越脑脊液和脑膜的大脑与颅骨骨髓之间细胞和分子的移动，目前有哪些证据？我们排除了与头部或颅骨创伤、颅骨骨折或缺损、癌症侵袭、脑脊液漏、自发性颅内低压、硬脊膜以及仅专注于脑膜淋巴管或物质从脑脊液到脑膜淋巴管通道的研究。该综述确定了16项研究，这些研究提供了大脑、脑膜和颅骨骨髓之间存在沟通的证据。据报道，细胞（如B细胞、T细胞和中性粒细胞）、细菌和物质（示踪剂、药物化合物）在大脑和颅骨之间通过。然而，大多数研究是在啮齿动物中进行的，这凸显了转化到人类研究的必要性。
