黏菌素治疗后产KPC的大肠埃希菌中mcr-1和OXA-48的获得
MCR-1 and OXA-48 Acquisition in KPC-Producing Escherichia coli after Colistin Treatment.
作者信息
Beyrouthy Racha, Robin Frederic, Lessene Aude, Lacombat Igor, Dortet Laurent, Naas Thierry, Ponties Valérie, Bonnet Richard
机构信息
CHU Clermont-Ferrand, Laboratoire de Bactériologie Clinique, Clermont-Ferrand, France.
Centre National de Référence de la Résistance aux Antibiotiques, laboratoire associé, Clermont-Ferrand, France.
出版信息
Antimicrob Agents Chemother. 2017 Jul 25;61(8). doi: 10.1128/AAC.02540-16. Print 2017 Aug.
Abstract
The spread of -encoding plasmids into carbapenem-resistant raises concerns about the emergence of untreatable bacteria. We report the acquisition of in a carbapenem-resistant strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the carbapenemase-producing strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 -encoding plasmid. This is the first report of in carbapenemase-encoding bacteria in France.
摘要
编码质粒向耐碳青霉烯菌的传播引发了对无法治疗的细菌出现的担忧。我们报告了一名从葡萄牙返回法国的患者在接受3周多粘菌素治疗后，其耐碳青霉烯菌株获得了[具体内容缺失]。全基因组测序显示，产碳青霉烯酶的[具体内容缺失]菌株获得了两个质粒，一个编码OXA-48的IncL质粒和一个编码[具体内容缺失]的IncX4质粒。这是法国关于碳青霉烯酶编码细菌中[具体内容缺失]的首例报告。
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