Shi Yingyun, Jia Renbing, Fan Xianqun
Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai, People's Republic of China.
Onco Targets Ther. 2017 May 8;10:2483-2489. doi: 10.2147/OTT.S130371. eCollection 2017.
Basal cell carcinoma (BCC) is a common malignant tumor throughout the world. One of the known risk factors of BCC is intense exposure to ultraviolet radiation. More than 50% of BCCs of the eyelid initially occur on the lower lid. The gold standard of diagnosis of BCC is histopathology. Treatment options for BCC consist of surgery, vismodegib, radiotherapy and imiquimod. Surgical excision using Mohs micrographic surgery or wide surgical excision with frozen section margin control is the first consideration for treatment of periocular BCC. Eyelid reconstruction should be carefully considered as both function and esthetic outcome in patients are important after clear excision of tumors. Exenteration is considered in the case of extensive orbital invasion or high-risk aggressive tumors in order to reduce the rate of recurrence.
基底细胞癌（BCC）是一种在全球范围内常见的恶性肿瘤。BCC已知的风险因素之一是强烈暴露于紫外线辐射。超过50%的眼睑基底细胞癌最初发生在下眼睑。基底细胞癌诊断的金标准是组织病理学。基底细胞癌的治疗选择包括手术、维莫德吉、放射治疗和咪喹莫特。使用莫氏显微外科手术进行手术切除或采用冰冻切片边缘控制的广泛手术切除是治疗眼周基底细胞癌的首要考虑方法。在肿瘤切除后，由于患者的功能和美学效果都很重要，因此应仔细考虑眼睑重建。对于广泛的眼眶侵犯或高危侵袭性肿瘤的情况，考虑进行眶内容剜除术以降低复发率。
