Iljin Aleksandra, Zieliński Tomasz, Antoszewski Bogusław, Sporny Stanisław
Department of Plastic, Reconstructive and Aesthetic Surgery, Institute of Surgery, Medical University of Lodz, Lodz, Poland.
Department of Dental Pathology, Medical University of Lodz, Lodz, Poland.
Postepy Dermatol Alergol. 2016 Feb;33(1):42-6. doi: 10.5114/pdia.2015.48039. Epub 2016 Feb 29.
Basal cell carcinoma (BCC) is the most common malignant neoplasm of the eyelids and surrounding structures, usually developing in the area of the lower lid and medial canthus. Invasive forms of BCC are connected with a high risk of recurrence, often due to incomplete excision of these lesions.
Clinical and pathological analysis of recurrent BCCs of the eyelids and surrounding structures.
We present clinical and pathological analysis including immunohistochemical reaction to Ki-67 antigen of 19 patients (11 women, 8 men) operated for recurrent BCCs of the eyelids in 2000-2012.
In most cases, recurrences were present on the lower lid and in the medial canthus. In 15 patients the histopathological type did not change and in 4 cases it transformed into more invasive forms. The values of Ki-67 index for primary BCCs ranged between 1% and 20%, and for relapsing lesions between 11% and 48%.
Proper clinical and pathological evaluation to determine the risk of relapse in BCCs of the eyelids and surrounding structures should include the analysis of prognostic factors, in particular location and size, histopathological type and radicalness of surgical treatment of primary BCCs. Clinical and pathological analysis of patients with recurrent BCC of the eyelids and surrounding structures should be combined with the evaluation of proliferation index Ki-67, which is essential for prognosis and choice of the appropriate therapeutic method.
基底细胞癌（BCC）是眼睑及周围结构最常见的恶性肿瘤，通常发生在下睑和内眦区域。侵袭性BCC具有较高的复发风险，这往往是由于这些病变切除不完全所致。
对眼睑及周围结构复发性BCC进行临床和病理分析。
我们对2000年至2012年因眼睑复发性BCC接受手术的19例患者（11例女性，8例男性）进行了临床和病理分析，包括对Ki-67抗原的免疫组化反应。
大多数情况下，复发发生在下睑和内眦。15例患者的组织病理学类型未发生变化，4例转变为更具侵袭性的形式。原发性BCC的Ki-67指数值在1%至20%之间，而复发性病变的Ki-67指数值在11%至48%之间。
为确定眼睑及周围结构BCC的复发风险，进行适当的临床和病理评估应包括对预后因素的分析，特别是位置和大小、组织病理学类型以及原发性BCC手术治疗的彻底性。对眼睑及周围结构复发性BCC患者的临床和病理分析应结合增殖指数Ki-67的评估，这对预后和选择合适的治疗方法至关重要。
