Yan Jingchao, Shen Jianwen, Li Ying, Tang Fengmin, Chen Nianzu
Department of Pharmacy, Eye Ear Nose Throat Hospital of Fudan University, No. 83, Fenyang Road, Shanghai, 200031, China.
Eur Arch Otorhinolaryngol. 2017 Aug;274(8):3103-3107. doi: 10.1007/s00405-017-4607-7. Epub 2017 May 15.
We undertook this survey about the use of clarithromycin in the Ear, Nose, and Throat (ENT) Outpatient Department of Fudan University Hospital to understand its utilization patterns and rational use. A survey of prescriptions given to outpatients was carried out, and detailed information of the patients, including age, sex, diagnosis, combined medication, and other information, was recorded in Excel spreadsheets. The rationale for each prescription was evaluated retrospectively. Based on our analysis, 82.5% of the clarithromycin prescriptions were for the treatment of rhinosinusitis. It was found that the parameters for the diagnosis of this condition were surprisingly broad and should have been more specific. In addition, the clarithromycin dosage regimen varied in clinical practice. For chronic rhinosinusitis, the duration of treatment was between 8 and 16 days, which was not sufficient. Moreover, clarithromycin was prescribed along with considerable numbers of pharmacotherapeutic anti-allergic drugs. Our survey indicated that improvements in the quality of clarithromycin prescriptions in otolaryngology outpatients should be made. Furthermore, the importance of medical education to patients should be emphasized. In addition, the interaction between clarithromycin and other anti-allergic drugs requires further investigation.
我们对复旦大学附属耳鼻喉科医院耳鼻喉科门诊使用克拉霉素的情况进行了这项调查，以了解其使用模式和合理使用情况。对门诊患者的处方进行了调查，并将患者的详细信息，包括年龄、性别、诊断、联合用药及其他信息，记录在Excel电子表格中。对每张处方的用药理由进行了回顾性评估。根据我们的分析，82.5%的克拉霉素处方用于治疗鼻窦炎。结果发现，该疾病的诊断标准出奇地宽泛，本应更加具体。此外，克拉霉素的给药方案在临床实践中各不相同。对于慢性鼻窦炎，治疗疗程为8至16天，这并不足够。此外，克拉霉素常与大量抗组胺药物联合使用。我们的调查表明，应提高耳鼻喉科门诊克拉霉素处方的质量。此外，应强调对患者进行医学教育的重要性。此外，克拉霉素与其他抗组胺药物之间的相互作用需要进一步研究。
