Kuklina E M, Nekrasova I V
Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, Perm, Russia.
Dokl Biol Sci. 2017 Mar;473(1):84-88. doi: 10.1134/S0012496617020028. Epub 2017 May 16.
Novel targets for action of the class IV semaphorin Seam4D have been identified in the immune system. The low-affinity CD72 receptor for Seam4D was detected not only on B lymphocytes, but also in a proportion of T cells, whereas the high-affinity semaphorin receptor, plexin B1, originally considered to belong to non-immune cells, proved to be in a great proportion of intact T and B cells. Seam4D is constitutively expressed in B cells, which, along with T cells, can serve as a source of both membrane and soluble semaphorin. The results obtained make significant adjustments in understanding of Seam4D effects in lymphoid cells.
在免疫系统中已鉴定出IV类信号素Seam4D发挥作用的新靶点。不仅在B淋巴细胞上检测到了Seam4D的低亲和力CD72受体，在一定比例的T细胞中也检测到了该受体；而高亲和力信号素受体——丛状蛋白B1，最初被认为属于非免疫细胞，但事实证明在很大比例的完整T细胞和B细胞中都有表达。Seam4D在B细胞中组成性表达，B细胞与T细胞一起，可作为膜信号素和可溶性信号素的来源。所获得的结果对理解Seam4D在淋巴细胞中的作用产生了重大调整。
