Beasley K L, Cooley G E, Kao G F, Lowitt M H, Burnett J W, Aurelian L
Department of Dermatology, University of Maryland School of Medicine, Baltimore, USA.
J Am Acad Dermatol. 1997 Nov;37(5 Pt 2):860-3. doi: 10.1016/s0190-9622(97)80012-6.
Large papillomatous lesions clinically resembling verrucous carcinoma may be caused by viruses other than human papillomavirus. We report a case of recurrent vegetations covering the entire vulva in a pregnant patient with common variable immunodeficiency. Herpes simplex virus was recovered from these lesions. The patient did not respond to intravenous acyclovir, but her lesions dramatically healed with two courses of intravenous foscarnet. Repeated biopsies may prove necessary in cases such as this to ensure proper diagnoses.
临床上类似疣状癌的大乳头状病变可能由人乳头瘤病毒以外的病毒引起。我们报告一例患有常见可变免疫缺陷的孕妇，其整个外阴出现复发性赘生物。从这些病变中分离出单纯疱疹病毒。患者对静脉注射阿昔洛韦无反应，但经两个疗程的静脉注射膦甲酸后，其病变显著愈合。对于此类病例，可能需要反复活检以确保正确诊断。
