Feng Shengjie
Department of Physiology, University of California, San Francisco, CA, USA.
Adv Exp Med Biol. 2017;976:9-23. doi: 10.1007/978-94-024-1088-4_2.
TRPC channels are the first identified members in the TRP family. They function as either homo- or heterotetramers regulating intracellular Ca concentration in response to numerous physiological or pathological stimuli. TRPC channels are nonselective cation channels permeable to Ca. The properties and the functional domains of TRPC channels have been identified by electrophysiological and biochemical methods. However, due to the large size, instability, and flexibility of their complexes, the structures of the members in TRPC family remain unrevealed. More efforts should be made on structure analysis and generating good tools, including specific antibodies, agonist, and antagonist.
瞬时受体电位通道（TRPC通道）是瞬时受体电位（TRP）家族中最早被鉴定出的成员。它们以同四聚体或异四聚体的形式发挥作用，响应多种生理或病理刺激来调节细胞内钙离子浓度。TRPC通道是对钙离子通透的非选择性阳离子通道。TRPC通道的特性和功能结构域已通过电生理和生化方法得以鉴定。然而，由于其复合物体积大、不稳定且具有灵活性，TRPC家族成员的结构仍未被揭示。在结构分析以及开发良好工具（包括特异性抗体、激动剂和拮抗剂）方面应付出更多努力。
