State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210023, China.
Org Lett. 2017 Jun 2;19(11):2909-2912. doi: 10.1021/acs.orglett.7b01145. Epub 2017 May 16.
Photoredox-catalyzed difunctionalizations of alkenes with O-acyl hydroxylamine derivatives are described. The solvent tunes the outcome of these reactions. Diamidation and oxidative amidation of alkenes can be achieved in CHCN and DMSO, respectively. A variety of 1,2-diamidates and α-amino ketones bearing many functional groups are prepared using Ir(ppy) as the photocatalyst under visible light irradiation.
本文描述了光氧化还原催化的烯烃与 O-酰基羟胺衍生物的双官能化反应。溶剂可以调控这些反应的结果。在 CHCN 和 DMSO 中，分别可以实现烯烃的二酰胺化和氧化酰胺化。使用 Ir(ppy)作为光催化剂，在可见光照射下，可以制备多种带有多种官能团的 1,2-二酰胺和α-氨基酸酮。
