Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Angew Chem Int Ed Engl. 2019 Aug 26;58(35):12286-12290. doi: 10.1002/anie.201906692. Epub 2019 Jul 25.
The potential of merging photoredox and nickel catalysis to perform multicomponent alkene difunctionalizations under visible-light irradiation is demonstrated here. Secondary and tertiary alkyl groups, as well as sulfonyl moieties can be added to the terminal position of the double bond with simultaneous arylation of the internal carbon atom in a single step under mild reaction conditions. The process, devoid of stoichiometric additives, benefits from the use of bench-stable and easy-to-handle reagents, is operationally simple, and tolerates a wide variety of functional groups.
本文展示了光氧化还原和镍催化合并在可见光照射下进行多组分烯烃双官能化的潜力。在温和的反应条件下，通过一步反应，可以将二级和三级烷基以及砜基部分添加到双键的末端位置，同时对内部碳原子进行芳基化。该过程不使用化学计量添加剂，受益于使用稳定且易于操作的试剂，操作简单，并能耐受各种官能团。
