异常惰性的髓过氧化物酶抗中性粒细胞胞浆抗体相关性血管炎：两例报告
Unusually indolent MPO-ANCA: associated vasculitis-report of two cases.
作者信息
Gatenby Paul A
机构信息
Immunology Department, The Canberra Hospital and Health Services, Medical School, the Australian National University, P.O. Box 11, Bldg 8, Level 1, The Canberra Hospital, Woden, Canberra, ACT, 2606, Australia.
出版信息
CEN Case Rep. 2013 Nov;2(2):131-133. doi: 10.1007/s13730-012-0045-y. Epub 2013 Feb 7.
Vasculitis associated with antineutrophil cytoplasmic antibodies specific to myeloperoxidase generally presents as a life- and organ-threatening disease that evolves over several months. It is a syndrome in which prompt diagnosis and therapy are important both in terms of short-term survival and long-term organ damage. Two cases with quite a different course, sustained and indolent with limited progression over many years, are described in this report. They are compared to cases in the literature. Indolent cases of granulomatous polyangiitis associated with antineutrophil cytoplasmic antibodies against proteinase-3 are well recognised, but these two cases of microscopic polyangiitis are almost unique.
与髓过氧化物酶特异性抗中性粒细胞胞浆抗体相关的血管炎通常表现为一种危及生命和器官的疾病，病程持续数月。这是一种综合征，就短期生存和长期器官损害而言，迅速诊断和治疗都很重要。本报告描述了两例病程截然不同的病例，病情持续且进展缓慢，多年来进展有限。将它们与文献中的病例进行了比较。与抗蛋白酶-3抗中性粒细胞胞浆抗体相关的肉芽肿性多血管炎的惰性病例已得到充分认识，但这两例显微镜下多血管炎病例几乎是独一无二的。
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