Steenman Marja, Lande Gilles
l'institut du thorax, INSERM, CNRS, UNIV Nantes, Nantes, France.
l'institut du thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France.
Biophys Rev. 2017 Apr;9(2):131-137. doi: 10.1007/s12551-017-0255-9. Epub 2017 Mar 20.
The world population continues to grow older rapidly, mostly because of declining fertility and increasing longevity. Since age represents the largest risk factor for cardiovascular disease, the prevalence of these pathologies increases dramatically with increasing age. In order to improve patient care and prevention for age-related cardiac diseases, insight should be gained from the analysis of processes involved in and leading to cardiac aging. It is from this perspective that we provide here an overview of changes associated with age in the heart on four levels: functional, structural, cellular and molecular. We highlight those changes that are in common with the development of the two major age-associated cardiac pathologies: heart failure and atrial fibrillation. These commonly affected processes in aging and cardiac pathophysiology may provide an explanation for the age risk factor in cardiac disease.
世界人口正在迅速老龄化，这主要是由于生育率下降和寿命延长。由于年龄是心血管疾病的最大风险因素，这些疾病的患病率会随着年龄的增长而急剧上升。为了改善对与年龄相关的心脏疾病的患者护理和预防，应该通过分析参与并导致心脏衰老的过程来获得深入了解。正是从这个角度出发，我们在此从功能、结构、细胞和分子四个层面概述了心脏中与年龄相关的变化。我们重点介绍了与两种主要的与年龄相关的心脏疾病（心力衰竭和心房颤动）发展过程中相同的变化。衰老和心脏病理生理学中这些普遍受影响的过程可能为心脏疾病中的年龄风险因素提供解释。
