来自越南海星多棘海盘车的极性甾体衍生物。

Polar steroid derivatives from the Vietnamese starfish Astropecten polyacanthus.

作者信息

Vien Le Thi, Hanh Tran Thi Hong, Hong Pham Thi, Thanh Nguyen Van, Huong Tran Thu, Cuong Nguyen Xuan, Nam Nguyen Hoai, Thung Do Cong, Kiem Phan Van, Minh Chau Van

机构信息

a Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.

b School of Chemical Engineering , Hanoi University of Science and Technology , Hanoi , Vietnam.

出版信息

Nat Prod Res. 2018 Jan;32(1):54-59. doi: 10.1080/14786419.2017.1329733. Epub 2017 May 16.

DOI:10.1080/14786419.2017.1329733

PMID:28511566

Abstract

Five polar steroid derivatives, including one new glycosylated polyhydroxysteroid namely polyacanthoside A (1), were isolated from the water-soluble materials from the MeOH extract of the Vietnamese starfish Astropecten polyacanthus using various chromatographic separations. The structure elucidation was confirmed by spectroscopic experiments such as HR-ESI-MS, 1D and 2D NMR. Among the isolated compounds, (20R,24S)-3β,6α,8,15β,24-pentahydroxy-5α-cholestane (3) showed significant cytotoxic effect against five human cancer cell lines as HepG2, KB, LNCaP, MCF7 and SK-Mel2 with the IC values from 18.03 ± 2.63 to 21.59 ± 3.23 μM.

摘要

从越南多棘海燕鱼（Astropecten polyacanthus）甲醇提取物的水溶性物质中，通过各种色谱分离方法分离出了5种极性甾体衍生物，其中包括一种新的糖基化多羟基甾体，即多棘苷A（1）。通过高分辨电喷雾电离质谱（HR-ESI-MS）、一维和二维核磁共振等光谱实验确定了其结构。在分离出的化合物中，（20R，24S）-3β，6α，8，15β，24-五羟基-5α-胆甾烷（3）对5种人类癌细胞系，即肝癌细胞系HepG2、口腔癌细胞系KB、前列腺癌细胞系LNCaP、乳腺癌细胞系MCF7和黑色素瘤细胞系SK-Mel2显示出显著的细胞毒性作用，其半数抑制浓度（IC）值为18.03±2.63至21.59±3.23μM。