来自糙海参的三萜四糖苷。

Triterpene tetraglycosides from the sea cucumber Stichopus horrens.

作者信息

Vien Le Thi, Hoang Le, Hanh Tran Thi Hong, Thanh Nguyen Van, Cuong Nguyen Xuan, Nam Nguyen Hoai, Thung Do Cong, Kiem Phan Van, Minh Chau Van

机构信息

a Institute of Marine Biochemistry (IMBC) , Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.

b Graduate University of Science and Technology, VAST , Hanoi , Vietnam.

出版信息

Nat Prod Res. 2018 May;32(9):1039-1043. doi: 10.1080/14786419.2017.1378206. Epub 2017 Sep 21.

DOI:10.1080/14786419.2017.1378206

PMID:28934865

Abstract

Using various chromatographic separations, three triterpene tetraglycosides (1-3), including one new compound, namely stichorrenoside E (1) along with thelenotoside B (2) and deacetyl thelenotoside B (3), were isolated from the MeOH extract of the Vietnamese sea cucumber Stichopus horrens. Their structures were confirmed by spectroscopic experiments, such as 1D and 2D NMR and HR-ESI-MS. Deacetylated thelenotoside B (3) is firstly isolated as a natural product. Among these compounds, thelenotoside B (2) showed strong cytotoxicities against five human cancer cell lines as HepG2, KB, LNCaP, MCF7 and SK-Mel2 with the IC values from 0.95 ± 0.08 to 1.90 ± 0.13 μM, whereas stichorrenoside E (1) and deacetyl thelenotoside B (3) exhibited significant activities with the IC values from 6.87 ± 0.25 to 11.62 ± 1.05 μM.

摘要

通过各种色谱分离方法，从越南海参刺参的甲醇提取物中分离出三种三萜四糖苷（1-3），其中包括一种新化合物，即刺参皂苷E（1）以及海兔皂苷B（2）和去乙酰海兔皂苷B（3）。它们的结构通过1D和2D NMR以及HR-ESI-MS等光谱实验得到证实。去乙酰海兔皂苷B（3）首次作为天然产物被分离出来。在这些化合物中，海兔皂苷B（2）对五种人类癌细胞系HepG2、KB、LNCaP、MCF7和SK-Mel2表现出较强的细胞毒性，IC值为0.95±0.08至1.90±0.13μM，而刺参皂苷E（1）和去乙酰海兔皂苷B（3）表现出显著活性，IC值为6.87±0.25至11.62±1.05μM。