Inhibitors of hepatitis C virus entry may be potent ingredients of optimal drug combinations.
作者信息
Padmanabhan Pranesh, Dixit Narendra M
机构信息
Queensland Brain Institute, University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia.
Department of Chemical Engineering, Indian Institute of Science, Bangalore 560012, India;
出版信息
Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4524-E4526. doi: 10.1073/pnas.1704531114. Epub 2017 May 16.
Abstract
摘要
相似文献
1
Inhibitors of hepatitis C virus entry may be potent ingredients of optimal drug combinations.丙型肝炎病毒进入抑制剂可能是最佳药物组合的有效成分。
Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4524-E4526. doi: 10.1073/pnas.1704531114. Epub 2017 May 16.
2
Discovery of highly potent small molecule Hepatitis C Virus entry inhibitors.发现高效的小分子丙型肝炎病毒进入抑制剂。
Bioorg Med Chem Lett. 2011 Nov 15;21(22):6852-5. doi: 10.1016/j.bmcl.2011.09.019. Epub 2011 Sep 16.
3
Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C.进入抑制剂与直接作用抗病毒药物的协同作用揭示了预防和治疗丙型肝炎的新组合。
Gut. 2015 Mar;64(3):483-94. doi: 10.1136/gutjnl-2013-306155. Epub 2014 May 21.
4
Identification of a series of 1,3,4-trisubstituted pyrazoles as novel hepatitis C virus entry inhibitors.鉴定一系列 1,3,4-三取代吡唑作为新型丙型肝炎病毒进入抑制剂。
Bioorg Med Chem Lett. 2013 Dec 1;23(23):6467-73. doi: 10.1016/j.bmcl.2013.09.039. Epub 2013 Sep 21.
5
Inhibition of hepatitis C entry: too soon to dismiss while many are still being denied treatment.丙型肝炎病毒进入的抑制作用：在许多人仍被拒绝治疗的情况下，现在摒弃还为时过早。
Gut. 2015 Apr;64(4):690-1. doi: 10.1136/gutjnl-2014-308396. Epub 2014 Oct 6.
6
Viral entry inhibition: too late for hepatitis C, but promising for other viral infections.病毒进入抑制：对丙型肝炎而言为时已晚，但对其他病毒感染颇具前景。
Gut. 2015 Mar;64(3):362-4. doi: 10.1136/gutjnl-2014-307452. Epub 2014 Aug 6.
7
A novel small molecule inhibitor of hepatitis C virus entry.一种新型丙型肝炎病毒进入抑制剂。
PLoS Pathog. 2010 Sep 2;6(9):e1001086. doi: 10.1371/journal.ppat.1001086.
8
Clinically Approved Ion Channel Inhibitors Close Gates for Hepatitis C Virus and Open Doors for Drug Repurposing in Infectious Viral Diseases.临床批准的离子通道抑制剂关闭丙型肝炎病毒的大门，并为传染病病毒疾病的药物再利用打开大门。
J Virol. 2017 Jan 3;91(2). doi: 10.1128/JVI.01914-16. Print 2017 Jan 15.
9
Meet the Classes of Directly Acting Antiviral Agents: Strengths and Weaknesses.认识直接作用抗病毒药物的类别：优势与劣势
Clin Liver Dis. 2015 Nov;19(4):605-17, v. doi: 10.1016/j.cld.2015.06.002. Epub 2015 Jul 26.
10
Oligonucleotide-Lipid Conjugates Forming G-Quadruplex Structures Are Potent and Pangenotypic Hepatitis C Virus Entry Inhibitors and .形成G-四链体结构的寡核苷酸-脂质缀合物是强效且泛基因型的丙型肝炎病毒进入抑制剂 以及 。
你提供的原文最后似乎不完整，有多余的“and.”，请你检查一下是否准确。完整准确的原文有助于更精准的翻译。
Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.02354-16. Print 2017 May.
引用本文的文献
1
Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection.联合靶向 TMPRSS2 和组织蛋白酶 B/L 可能对 SARS-CoV-2 感染具有协同作用。
PLoS Comput Biol. 2020 Dec 8;16(12):e1008461. doi: 10.1371/journal.pcbi.1008461. eCollection 2020 Dec.
2
Mutational pathway maps and founder effects define the within-host spectrum of hepatitis C virus mutants resistant to drugs.突变途径图谱和起源效应定义了宿主内丙型肝炎病毒耐药突变体的范围。
PLoS Pathog. 2019 Apr 1;15(4):e1007701. doi: 10.1371/journal.ppat.1007701. eCollection 2019 Apr.
3
Building a mechanistic mathematical model of hepatitis C virus entry.建立丙型肝炎病毒进入的机制数学模型。
PLoS Comput Biol. 2019 Mar 18;15(3):e1006905. doi: 10.1371/journal.pcbi.1006905. eCollection 2019 Mar.
4
Interferon at the cellular, individual, and population level in hepatitis C virus infection: Its role in the interferon-free treatment era.在丙型肝炎病毒感染中，干扰素在细胞、个体和群体水平上的作用：在无干扰素治疗时代的作用。
Immunol Rev. 2018 Sep;285(1):55-71. doi: 10.1111/imr.12689.
5
Modelling how responsiveness to interferon improves interferon-free treatment of hepatitis C virus infection.建立模型，研究对干扰素的反应性如何改善丙型肝炎病毒感染的无干扰素治疗。
PLoS Comput Biol. 2018 Jul 12;14(7):e1006335. doi: 10.1371/journal.pcbi.1006335. eCollection 2018 Jul.
6
Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments.对帕德马纳班和迪克西特的回复：丙型肝炎病毒进入抑制剂，用于优化基于直接作用抗病毒药物的治疗。
Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4527-E4529. doi: 10.1073/pnas.1705234114. Epub 2017 May 16.
本文引用的文献
1
Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection.量化抗病毒活性可优化针对丙型肝炎病毒感染的药物组合。
Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1922-1927. doi: 10.1073/pnas.1610197114. Epub 2017 Feb 7.
2
Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin.Civacir丙型肝炎免疫球蛋白对丙型肝炎病毒耐药变异株的广泛中和作用。
Hepatology. 2016 Nov;64(5):1495-1506. doi: 10.1002/hep.28767. Epub 2016 Sep 30.
3
Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals.丙型肝炎病毒的细胞进入：一种针对新型抗病毒策略的靶点，以解决直接作用抗病毒药物的局限性。
Hepatol Int. 2016 Sep;10(5):741-8. doi: 10.1007/s12072-016-9724-7. Epub 2016 Apr 5.
4
Novel small-molecule inhibitors of hepatitis C virus entry block viral spread and promote viral clearance in cell culture.新型丙型肝炎病毒进入抑制剂可阻断病毒在细胞培养中的传播并促进病毒清除。
PLoS One. 2012;7(4):e35351. doi: 10.1371/journal.pone.0035351. Epub 2012 Apr 24.
5
A quantitative basis for antiretroviral therapy for HIV-1 infection.抗 HIV-1 感染的抗逆转录病毒治疗的定量基础。
Nat Med. 2012 Feb 19;18(3):446-51. doi: 10.1038/nm.2649.
6
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.EGFR 和 EphA2 是丙型肝炎病毒进入宿主的因素，也是抗病毒治疗的潜在靶点。
Nat Med. 2011 May;17(5):589-95. doi: 10.1038/nm.2341. Epub 2011 Apr 24.
7
Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors.小分子清道夫受体 BI 拮抗剂是有效的 HCV 进入抑制剂。
J Hepatol. 2011 Jan;54(1):48-55. doi: 10.1016/j.jhep.2010.06.024. Epub 2010 Aug 21.
8
A novel small molecule inhibitor of hepatitis C virus entry.一种新型丙型肝炎病毒进入抑制剂。
PLoS Pathog. 2010 Sep 2;6(9):e1001086. doi: 10.1371/journal.ppat.1001086.
9
The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein.抗丙型肝炎病毒抗体的中和活性受E2包膜蛋白上特定聚糖的调节。
J Virol. 2007 Aug;81(15):8101-11. doi: 10.1128/JVI.00127-07. Epub 2007 May 23.
10
Different domains of CD81 mediate distinct stages of hepatitis C virus pseudoparticle entry.CD81的不同结构域介导丙型肝炎病毒假病毒颗粒进入的不同阶段。
J Virol. 2006 May;80(10):4940-8. doi: 10.1128/JVI.80.10.4940-4948.2006.
Zotero 插件