Iannetti P, Morellini M, Raucci U, Cappellacci S
Department of Pediatrics, University La Sapienza, Rome, Italy.
Brain Dev. 1988;10(4):256-8. doi: 10.1016/s0387-7604(88)80008-1.
Thirty-one epileptic patients, selected from among 900 children with previous febrile convulsions and subsequent epilepsy, were typed for HLA antigens. In 16 of the 31 patients CMV was isolated from the urine shortly after the appearance of spontaneous fits; in the remaining 15 patients the virus was never detected. All the examined children were typed for 14 HLA-A, 23 HLA-B, 7 HLA-C and 9 HLA-DR specificities, and compared with a group of healthy subjects. The HLA-A11 antigen was present in 25% of the children with chronic CMV infection and epilepsy, and absent in patients with epilepsy but without CMV infection (p less than 0.02). The possibility that the A11 antigen is a marker of the predisposing genes for CMV infection in children with epilepsy following FC is proposed.
从900名曾有高热惊厥继而患癫痫的儿童中选取了31名癫痫患者，对其进行HLA抗原分型。31名患者中有16名在出现自发性惊厥后不久从尿液中分离出巨细胞病毒（CMV）；其余15名患者从未检测到该病毒。对所有受试儿童进行了14种HLA - A、23种HLA - B、7种HLA - C和9种HLA - DR特异性分型，并与一组健康受试者进行比较。HLA - A11抗原在25%的慢性CMV感染合并癫痫的儿童中存在，而在无CMV感染的癫痫患者中不存在（p<0.02）。提出A11抗原可能是高热惊厥后癫痫儿童CMV感染易感基因的标志物。
