利用生物电阻抗分析中国年轻健康人群的身体成分：方法学考量

Body Composition Analysis by Using Bioelectrical Impedance in a Young Healthy Chinese Population: Methodological Considerations.

作者信息

Chen Wei, Jiang Hua, Yang Jiong-Xian, Yang Hao, Liu Jing-Min, Zhen Xiu-Yuan, Feng Lian-Jun, Yu Jian-Chun

机构信息

1 Department of Enteral and Parenteral Nutrition, Peking Union Medical College Hospital, Medical School of Tsinghua University, Beijing, China.

2 Department of Computational Mathematics and Biostatistics, Metabolomics and Multidisciplinary Laboratory for Trauma Research, Sichuan Provincial People's Hospital and Sichuan Academy of Medical Sciences, Chengdu, China.

出版信息

Food Nutr Bull. 2017 Jun;38(2):172-181. doi: 10.1177/0379572117697534. Epub 2017 Mar 14.

DOI:10.1177/0379572117697534

PMID:28513264

Abstract

OBJECTIVE

To develop a new bioelectrical impedance analysis (BIA) model for analyzing body composition by using isotope dilution, magnetic resonance imaging (MRI), and dual-energy X-ray absorptiometry (DEXA) as the reference methods in young healthy Chinese populations.

METHODS

Thirty healthy participants were enrolled. Their body composition was analyzed using BIA and 3 reference methods. We established a model that uniformed data from 3 references methods (isotope, MRI, and DEXA) into 1 formula. This model was further validated with 209 participants.

RESULTS

The following BIA body composition adjustment model was developed: [Formula: see text], where X represents the impedance index; when K = 1, 2, and 3, Y represents total body water, fat mass, and bone mass, respectively. The prediction accuracy of this formula was 93.3%. By incorporating the data matrix, the protein mass was calculated using BIA: [Formula: see text]. In the verification part of this study, the lean body mass measured using DEXA and BIA was 43.02 ± 8.34 kg and 45.85 ± 8.81 kg, respectively. Analysis indicated that the model fit was extremely favorable ( R = .9997, P < .001).

CONCLUSIONS

The accuracy of BIA measurement on body composition and protein mass is significantly improved by our work.

摘要

目的

通过使用同位素稀释法、磁共振成像（MRI）和双能X线吸收法（DEXA）作为年轻健康中国人群的参考方法，开发一种用于分析身体成分的新型生物电阻抗分析（BIA）模型。

方法

招募了30名健康参与者。使用BIA和3种参考方法对他们的身体成分进行分析。我们建立了一个将来自3种参考方法（同位素、MRI和DEXA）的数据统一到一个公式中的模型。该模型在209名参与者中进一步得到验证。

结果

开发了以下BIA身体成分调整模型：[公式：见正文]，其中X代表阻抗指数；当K = 1、2和3时，Y分别代表总体水、脂肪量和骨量。该公式的预测准确率为93.3%。通过纳入数据矩阵，使用BIA计算蛋白质质量：[公式：见正文]。在本研究的验证部分，使用DEXA和BIA测量的去脂体重分别为43.02±8.34kg和45.85±8.81kg。分析表明模型拟合非常良好（R = 0.9997，P < 0.001）。