1Baker Heart and Diabetes Institute, Melbourne, VIC, AUSTRALIA; 2Department of Physiology, School of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, AUSTRALIA; 3School of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, AUSTRALIA; 4Menzies School of Health Research, Darwin, NT, AUSTRALIA; 5Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD; 6Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD; 7Melbourne School of Population and Global Health, University of Melbourne, VIC, AUSTRALIA; 8Swinburne University of Technology, Melbourne VIC, AUSTRALIA; 9School of Public Health, University of Queensland, Brisbane, QLD, AUSTRALIA; 10School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; and 11Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, AUSTRALIA.
Med Sci Sports Exerc. 2017 Oct;49(10):2040-2047. doi: 10.1249/MSS.0000000000001317.
Television (TV) viewing time is associated with increased risk of all-cause, cardiovascular and cancer mortality. Although TV time is detrimentally associated with key inflammatory markers, the associations of TV time with other inflammatory-related mortality (with a predominant inflammatory, oxidative or infectious component, but not attributable to cancer or cardiovascular causes), are unknown.
Among 8933 Australian adults (4593 never-smokers) from the baseline (1999-2000) Australian Diabetes, Obesity and Lifestyle Study (median follow-up, 13.6 yr), we examined TV time in relation to noninflammatory and inflammatory-related mortality (not attributable to cancer or cardiovascular causes, hereafter "inflammatory-related" mortality). Because smoking has a significant inflammatory component, we also examined this relationship in never-smokers.
Of 896 deaths, 248 were attributable to cardiovascular disease, 346 to cancer, 130 to other inflammatory-related causes (71 for never-smokers), and 172 to noninflammatory-related causes (87 for never-smokers). After multivariate adjustment for age, sex, education, household income, smoking status, alcohol intake, energy intake, diet, and cardiometabolic risk biomarkers (model 3), every additional hours per day of TV time was associated with increased risk of inflammatory-related mortality in the overall population (hazard ratio, 1.12; 95% confidence interval, 1.00-1.25) and in never-smokers (1.18; 1.00, 1.40). These results were attenuated after additional adjustment for leisure-time physical activity. After multivariate adjustment (model 3), no association was observed for noninflammatory mortality in the overall population (0.95; 0.85, 1.07), but risk tended to decrease for never-smokers (0.85; 0.75, 1.02).
In summary, before adjustment for leisure-time physical activity, TV time was associated with increased risk of inflammatory-related mortality. This is consistent with the hypothesis that high TV viewing may be associated with a chronic inflammatory state.
看电视（TV）时间与全因、心血管疾病和癌症死亡率的增加有关。尽管看电视时间与关键的炎症标志物呈不利关联，但看电视时间与其他炎症相关死亡率（主要与炎症、氧化或感染因素有关，但与癌症或心血管原因无关）之间的关联尚不清楚。
在基线（1999-2000 年）澳大利亚糖尿病、肥胖和生活方式研究（中位随访时间 13.6 年）的 8933 名澳大利亚成年人（4593 名从不吸烟者）中，我们研究了看电视时间与非炎症和炎症相关死亡率（与癌症或心血管原因无关，以下简称“炎症相关”死亡率）之间的关系。由于吸烟具有显著的炎症成分，我们还在从不吸烟者中研究了这种关系。
在 896 例死亡中，248 例归因于心血管疾病，346 例归因于癌症，130 例归因于其他炎症相关原因（71 例为从不吸烟者），172 例归因于非炎症相关原因（87 例为从不吸烟者）。在多变量调整年龄、性别、教育程度、家庭收入、吸烟状况、饮酒量、能量摄入、饮食和心血管代谢风险生物标志物（模型 3）后，每天看电视时间每增加 1 小时，与全人群炎症相关死亡率增加相关（风险比，1.12；95%置信区间，1.00-1.25），从不吸烟者风险增加（1.18；1.00，1.40）。这些结果在进一步调整休闲时间体力活动后减弱。在多变量调整（模型 3）后，全人群非炎症死亡率无相关性（0.95；0.85，1.07），但从不吸烟者风险趋于降低（0.85；0.75，1.02）。
总之，在未调整休闲时间体力活动的情况下，看电视时间与炎症相关死亡率的增加有关。这与高看电视时间可能与慢性炎症状态有关的假说一致。
