人类第1组固有淋巴细胞表面CD3ε呈阴性，但表达CD5。
Human Group 1 Innate Lymphocytes Are Negative for Surface CD3ε but Express CD5.
作者信息
Roan Florence, Ziegler Steven F
机构信息
Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, USA.
Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, USA; Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195, USA.
出版信息
Immunity. 2017 May 16;46(5):758-759. doi: 10.1016/j.immuni.2017.04.024.
Abstract
Simoni and colleagues recently published a mass cytometry (CyTOF)-based analysis of innate lymphoid cell (ILC) subsets across different human tissues (Simoni et al., 2017). Helper-type ILC1 cells were undetectable in these analyses, and the authors suggest that ILC1s reported in previous studies were likely attributable to T cell contamination. Although much of the heterogeneity and complexity within the ILC1 population remains to be fully delineated, we believe there is ample evidence that these cells constitute a unique population(s) clearly distinct from conventional T cells.
摘要
西蒙尼及其同事最近发表了一项基于质谱流式细胞术（CyTOF）对不同人体组织中固有淋巴细胞（ILC）亚群的分析（西蒙尼等人，2017年）。在这些分析中未检测到辅助型ILC1细胞，作者认为先前研究中报道的ILC1可能归因于T细胞污染。尽管ILC1群体中的许多异质性和复杂性仍有待充分阐明，但我们相信有充分证据表明这些细胞构成了一个独特的群体，明显不同于传统T细胞。
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