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CD5 表面表达标志着血管内的人类先天淋巴细胞，它们具有独特的个体发生和迁移到肺部的特征。

CD5 Surface Expression Marks Intravascular Human Innate Lymphoid Cells That Have a Distinct Ontogeny and Migrate to the Lung.

机构信息

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

出版信息

Front Immunol. 2021 Nov 18;12:752104. doi: 10.3389/fimmu.2021.752104. eCollection 2021.

DOI:10.3389/fimmu.2021.752104
PMID:34867984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8640955/
Abstract

Innate lymphoid cells (ILCs) contribute to immune defense, yet it is poorly understood how ILCs develop and are strategically positioned in the lung. This applies especially to human ILCs due to the difficulty of studying them . Here we investigated the ontogeny and migration of human ILCs with a humanized mouse model ("MISTRG") expressing human cytokines. In addition to known tissue-resident ILC subsets, we discovered CD5-expressing ILCs that predominantly resided within the lung vasculature and in the circulation. CD5 ILCs contained IFNγ-producing mature ILC1s as well as immature ILCs that produced ILC effector cytokines under polarizing conditions . CD5 ILCs had a distinct ontogeny compared to conventional CD5 ILCs because they first appeared in the thymus, spleen and liver rather than in the bone marrow after transplantation of MISTRG mice with human CD34 hematopoietic stem and progenitor cells. Due to their strategic location, human CD5 ILCs could serve as blood-borne sentinels, ready to be recruited into the lung to respond to environmental challenges. This work emphasizes the uniqueness of human CD5 ILCs in terms of their anatomical localization and developmental origin compared to well-studied CD5 ILCs.

摘要

固有淋巴细胞 (ILC) 有助于免疫防御，但人们对它们在肺部的发育和定位策略知之甚少。由于研究人类 ILC 的困难，这尤其适用于人类 ILC。在这里，我们使用表达人类细胞因子的人源化小鼠模型（“MISTRG”）研究了人类 ILC 的发生和迁移。除了已知的组织驻留 ILC 亚群外，我们还发现了表达 CD5 的 ILC，它们主要存在于肺部血管和循环中。CD5 ILC 包含产生 IFNγ 的成熟 ILC1 以及在极化条件下产生 ILC 效应细胞因子的不成熟 ILC。与传统的 CD5 ILC 相比，CD5 ILC 的发生具有明显的不同，因为它们首先出现在胸腺、脾脏和肝脏中，而不是在移植了具有人 CD34 造血干细胞和祖细胞的 MISTRG 小鼠的骨髓中。由于其战略位置，人类 CD5 ILC 可以作为血液传播的哨兵，随时准备被招募到肺部以应对环境挑战。这项工作强调了与研究充分的 CD5 ILC 相比，人类 CD5 ILC 在解剖定位和发育起源方面的独特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5507/8640955/202789f47ed3/fimmu-12-752104-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5507/8640955/3501eae71b1b/fimmu-12-752104-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5507/8640955/4c1c6a5b5088/fimmu-12-752104-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5507/8640955/4496769498bc/fimmu-12-752104-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5507/8640955/28eb75917277/fimmu-12-752104-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5507/8640955/d0119b211497/fimmu-12-752104-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5507/8640955/202789f47ed3/fimmu-12-752104-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5507/8640955/3501eae71b1b/fimmu-12-752104-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5507/8640955/195c30fe3eeb/fimmu-12-752104-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5507/8640955/4c1c6a5b5088/fimmu-12-752104-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5507/8640955/4496769498bc/fimmu-12-752104-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5507/8640955/28eb75917277/fimmu-12-752104-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5507/8640955/d0119b211497/fimmu-12-752104-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5507/8640955/202789f47ed3/fimmu-12-752104-g007.jpg

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