Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Immunity. 2017 May 16;46(5):771-773. doi: 10.1016/j.immuni.2017.04.023.
Anti-Dengue virus (DENV) antibodies can be either protective or pathogenic in humans with prior DENV infection. In a recent issue of Science, Bardina et al. (2017) demonstrated that passive transfer of immune plasma against DENV and West Nile virus (WNV) can enhance Zika virus (ZIKV) infection and pathogenesis in mice.
抗登革热病毒 (DENV) 抗体在既往感染过 DENV 的人群中可能具有保护作用，也可能具有致病性。在最近一期的《科学》杂志上， Bardina 等人（2017 年）证明，针对 DENV 和西尼罗河病毒 (WNV) 的免疫血浆的被动转移可以增强寨卡病毒 (ZIKV) 在小鼠中的感染和发病机制。
