Laboratory of Molecular Immunology, The Rockefeller University, New York, NY
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
J Exp Med. 2019 Oct 7;216(10):2302-2315. doi: 10.1084/jem.20191061. Epub 2019 Aug 14.
Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015-2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.
寨卡病毒（ZIKV）感染孕妇可导致先天畸形，包括小头畸形。然而，其发生率差异较大，且相关危险因素仍不清楚。本研究分析了 2015-2016 年寨卡病毒流行期间巴西分娩孕妇的血清抗体对寨卡病毒和其他黄病毒的反应。与低滴度相比，中和抗体增强滴度处于中等或更高水平的寨卡病毒感染妊娠更易导致小头畸形儿出生（P < 0.0001）。此外，对感染寨卡病毒的妊娠猕猴进行分析显示，抗体增强滴度较高的母亲其胎儿脑损伤更常见。因此，母体抗体的特征与寨卡病毒相关的小头畸形的发生有关，并可能与之相关。
