Department of Nutrition and Health, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa, Minas Gerais 36570-000, Brazil.
Department of Veterinary, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa, Minas Gerais 36570-000, Brazil.
Biomed Pharmacother. 2017 Jul;91:938-945. doi: 10.1016/j.biopha.2017.05.015. Epub 2017 May 13.
Due to the high content of bioactive compounds, herbal teas are being investigated as adjuvant in chronic disease management. Studies have shown that mango leaf tea contain mangiferin, total phenolics and antioxidants, compounds with many functional properties. Therefore, this study aims to evaluate the anti-obesity effects of tea from Mangifera indica L. leaves, Ubá variety (TML), in obese rats fed a high-fat diet (HFD). For this, adult male Wistar rats were divided into three groups (n=8): the control group (fed AIN-93 diet), obese group (fed a HFD) and treated group (fed a HFD and supplemented with TML for 8 weeks). We analysed biometric measures and serum biochemical parameters of metabolic control, inflammation and oxidative stress biomarkers, histomorphometry of visceral adipose tissue and mRNA expression of peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PPAR-γ), lipoprotein lipase (LPL) and fatty acid synthase (FAS). The consumption of TML (24.7±2.1mL/day) exerted antioxidant and anti-inflammatory effects, increasing total antioxidant capacity and interleukin-10 serum concentrations, reduced abdominal fat accumulation, upregulated PPAR-γ and LPL and downregulated FAS expression. Our data suggest that TML has therapeutic potential in treating obesity and related diseases through regulating the expression of transcriptional factors and enzymes associated with adipogenesis.
由于含有丰富的生物活性化合物，草药茶正被作为辅助治疗慢性疾病的方法而受到研究。研究表明，芒果叶茶含有芒果苷、总酚类物质和抗氧化剂，这些化合物具有许多功能特性。因此，本研究旨在评估 Ubá 品种芒果叶茶（TML）对高脂肪饮食（HFD）喂养肥胖大鼠的减肥效果。为此，将成年雄性 Wistar 大鼠分为三组（n=8）：对照组（喂养AIN-93 饮食）、肥胖组（喂养 HFD）和治疗组（喂养 HFD 并补充 TML 8 周）。我们分析了体重和血清生化参数、代谢控制、炎症和氧化应激生物标志物、内脏脂肪组织的组织形态计量学以及过氧化物酶体增殖物激活受体γ共激活因子 1α（PPAR-γ）、脂蛋白脂肪酶（LPL）和脂肪酸合酶（FAS）的 mRNA 表达。TML（24.7±2.1mL/天）的摄入具有抗氧化和抗炎作用，增加了总抗氧化能力和血清白细胞介素-10 浓度，减少了腹部脂肪堆积，上调了 PPAR-γ 和 LPL，并下调了 FAS 的表达。我们的数据表明，TML 通过调节与脂肪生成相关的转录因子和酶的表达，具有治疗肥胖症及相关疾病的潜力。
