Department of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea.
Department of Life Sciences, Yeungnam University, Gyeongsan 38541, Korea.
Nutrients. 2017 Sep 10;9(9):999. doi: 10.3390/nu9090999.
Recent studies have reported that the aerial parts of ginseng contain various saponins, which have anti-oxidative, anti-inflammatory, and anti-obesity properties similar to those of ginseng root. However, the leaf extracts of Korean ginseng have not yet been investigated. In this study, we demonstrate the anti-obesity effects of green leaf and dried leaf extracts (GL and DL, respectively) of ginseng in high-fat diet (HFD)-induced obese rats. The administration of GL and DL to HFD-induced obese rats significantly decreased body weight (by 96.5% and 96.7%, respectively), and epididymal and abdominal adipose tissue mass. Furthermore, DL inhibited the adipogenesis of 3T3-L1 adipocytes through regulation of the expression of key adipogenic regulators, such as peroxisome proliferator-activated receptor (PPAR)-γ and CCAAT/enhancer-binding protein (C/EBP)-α. In contrast, GL had little effect on the adipogenesis of 3T3-L1 adipocytes but greatly increased the protein expression of PPARγ compared with that in untreated cells. These results were not consistent with an anti-obesity effect in the animal model, which suggested that the anti-obesity effect of GL in vivo resulted from specific factors released by other organs, or from increased energy expenditure. To our knowledge, these findings are the first evidence for the anti-obesity effects of the leaf extracts of Korean ginseng in vivo.
最近的研究报告称，人参的地上部分含有各种皂苷，具有与人参根相似的抗氧化、抗炎和抗肥胖特性。然而，韩国人参的叶提取物尚未得到研究。在这项研究中，我们证明了人参的绿叶和干叶提取物（分别为 GL 和 DL）在高脂肪饮食（HFD）诱导的肥胖大鼠中的抗肥胖作用。将 GL 和 DL 给予 HFD 诱导的肥胖大鼠可显著降低体重（分别降低 96.5%和 96.7%），并降低附睾和腹部脂肪组织的质量。此外，DL 通过调节过氧化物酶体增殖物激活受体（PPAR）-γ和 CCAAT/增强子结合蛋白（C/EBP）-α等关键脂肪生成调节剂的表达来抑制 3T3-L1 脂肪细胞的脂肪生成。相比之下，GL 对 3T3-L1 脂肪细胞的脂肪生成几乎没有影响，但与未经处理的细胞相比，大大增加了 PPARγ 的蛋白表达。这些结果与动物模型中的抗肥胖作用不一致，这表明 GL 在体内的抗肥胖作用是由其他器官释放的特定因子或增加的能量消耗引起的。据我们所知，这些发现是韩国人参叶提取物在体内具有抗肥胖作用的首次证据。
