Department of Chemistry, Indian Institute of Technology , Kharagpur 721302, West Bengal, India.
Langmuir. 2017 Jun 13;33(23):5891-5899. doi: 10.1021/acs.langmuir.7b01158. Epub 2017 May 30.
In this article, we have reported the synthesis and physicochemical characterization of a novel l-glycine amino acid derived cholesterol based surface active ionic liquid (SAIL). This SAIL has been explored for the preparation of ionic liquid (IL)-in-oil microemulsions and vesicles. The formation of IL-in-oil microemulsion is characterized by construction of a ternary phase diagram, dynamic light scattering (DLS) measurement, proton nuclear magnetic resonance (H NMR) study, fluorescence measurement using coumarin 480 (C-480) as a molecular probe, and also by recording the diffusion behavior of the molecular probe rhodamine 6G (R6G) in microemulsion droplets through the fluorescence correlation spectroscopy (FCS) technique. Similarly, the spontaneous vesicle formation from the SAIL in water has been established using DLS, transmission electron microscopy (TEM), cryogenic-transmission electron microscopy (cryo-TEM), field emission scanning electron microscopy (FESEM), atomic force microscopy (AFM), FCS, and fluorescence lifetime imaging microscopy (FLIM) measurements. These aggregates may potentially serve as good biomimicking models and possible drug carriers.
本文报道了一种新型的 l-甘氨酸衍生胆固醇基表面活性离子液体（SAIL）的合成及理化特性。研究了该 SAIL 用于制备离子液体（IL）-油微乳液和囊泡。通过构建三元相图、动态光散射（DLS）测量、质子核磁共振（H NMR）研究、香豆素 480（C-480）作为分子探针的荧光测量以及通过荧光相关光谱（FCS）技术记录分子探针罗丹明 6G（R6G）在微乳液液滴中的扩散行为，研究了 IL-油微乳液的形成。同样，通过 DLS、透射电子显微镜（TEM）、低温透射电子显微镜（cryo-TEM）、场发射扫描电子显微镜（FESEM）、原子力显微镜（AFM）、FCS 和荧光寿命成像显微镜（FLIM）测量，研究了 SAIL 在水中自发形成囊泡。这些聚集体可能作为良好的仿生模型和潜在的药物载体。
